Prominent theories of consciousness emphasise different aspects of neurobiology, such as
the integration and diversity of information processing within the brain. Here, we combine …

Loss of cortical integration and changes in the dynamics of electrophysiological brain
signals characterize the transition from wakefulness towards unconsciousness. In this study …

Aim In order to successfully detect, classify, prognosticate, and develop targeted therapies
for patients with disorders of consciousness (DOC), it is crucial to improve our mechanistic …

Brain states are frequently represented using a unidimensional scale measuring the
richness of subjective experience (level of consciousness). This description assumes a …

This proceedings article presents actionable research targets on the basis of the
presentations and discussions at the 2nd Curing Coma National Institutes of Health (NIH) …

Background General anaesthetics generate spatially defined brain oscillations in the EEG
that relate fundamentally to neural-circuit architecture. Few studies detailing the neural …

Although chronic vagus nerve stimulation (VNS) is an established treatment for medically-
intractable childhood epilepsy, there is considerable heterogeneity in seizure response and …

Resting-state functional magnetic resonance imaging evolves through a repertoire of
functional connectivity patterns which might reflect ongoing cognition, as well as the …

The claustrum is a brain region whose function remains unknown, though many
investigators suggest it plays a role in conscious attention. Resting-state functional magnetic …

Vagus nerve stimulation (VNS) is a low-risk surgical option for patients with drug resistant
epilepsy, although it is impossible to predict which patients may respond to VNS treatment …