Alzheimer's Disease (AD) is the most common form of dementia, affecting almost 50 million
of people around the world, characterized by a complex and age-related progressive …

The amyloid cascade hypothesis has always been a research focus in the therapeutic field
of Alzheimer's disease (AD) since it was put forward. Numerous researchers attempted to …

Background Previously we reported the clinical safety and pharmacological activity of
buntanetap (known as Posiphen or ANVS401) in healthy volunteers and mild cognitive …

Abstract Introduction People with Down syndrome (DS) are predisposed to Alzheimer's
disease (AD). The amyloid hypothesis informs studies of AD. In AD‐DS, but not sporadic AD …

The Amyloid precursor protein (APP) is a transmembrane glycoprotein from which amyloid-β
(Aβ) peptides are generated after proteolytic cleavage. Aβ peptides are the main constituent …

Genetic, biochemical, and anatomical grounds led to the proposal of the amyloid cascade
hypothesis centered on the accumulation of amyloid beta peptides (Aβ) to explain …

Amyloid precursor protein profusion in Trisomy 21, also called Down Syndrome (DS), is
rooted in the genetic determination of Alzheimer's disease (AD). With the recent …

Background Amyloid beta protein (Aβ) is a treatment target in Alzheimer's Disease (AD).
Lowering production of its parent protein, APP, has benefits in preclinical models. Posiphen …

Dysregulation of brain insulin signaling with reduced downstream neuronal survival and
plasticity mechanisms are fundamental abnormalities observed in Alzheimer disease (AD) …

Down syndrome (DS), also known as trisomy 21, is a genetic disorder caused by triplication
of Chromosome 21. Gene triplication may compromise different body functions but invariably …