Microfluidic cell sorting: a review of the advances in the separation of cells from debulking to rare cell isolation

CW Shields Iv, CD Reyes, GP López - Lab on a Chip, 2015 - pubs.rsc.org
Accurate and high throughput cell sorting is a critical enabling technology in molecular and
cellular biology, biotechnology, and medicine. While conventional methods can provide high …

Lab on a chip for continuous-flow magnetic cell separation

M Hejazian, W Li, NT Nguyen - Lab on a Chip, 2015 - pubs.rsc.org
Separation of cells is a key application area of lab-on-a-chip (LOC) devices. Among the
various methods, magnetic separation of cells utilizing microfluidic devices offers the merits …

Acoustic separation of circulating tumor cells

P Li, Z Mao, Z Peng, L Zhou, Y Chen… - Proceedings of the …, 2015 - National Acad Sciences
Circulating tumor cells (CTCs) are important targets for cancer biology studies. To further
elucidate the role of CTCs in cancer metastasis and prognosis, effective methods for …

[HTML][HTML] Organs-on-chips technologies–A guide from disease models to opportunities for drug development

AG Monteduro, S Rizzato, G Caragnano… - Biosensors and …, 2023 - Elsevier
Current in-vitro 2D cultures and animal models present severe limitations in recapitulating
human physiopathology with striking discrepancies in estimating drug efficacy and side …

Microfluidics for sperm analysis and selection

R Nosrati, PJ Graham, B Zhang, J Riordon… - Nature Reviews …, 2017 - nature.com
Infertility is a growing global health issue with far-reaching socioeconomic implications. A
downward trend in male fertility highlights the acute need for affordable and accessible …

Size-based separation methods of circulating tumor cells

SJ Hao, Y Wan, YQ **a, X Zou, SY Zheng - Advanced drug delivery reviews, 2018 - Elsevier
Circulating tumor cells (CTCs) originate from the primary tumor mass and enter into the
peripheral bloodstream. Compared to other “liquid biopsy” portfolios such as exosome …

Nucleic‐acid structures as intracellular probes for live cells

D Samanta, SB Ebrahimi, CA Mirkin - Advanced Materials, 2020 - Wiley Online Library
The chemical composition of cells at the molecular level determines their growth,
differentiation, structure, and function. Probing this composition is powerful because it …

Microfluidic isolation and enrichment of nanoparticles

Y **e, J Rufo, R Zhong, J Rich, P Li, KW Leong… - ACS …, 2020 - ACS Publications
Over the past decades, nanoparticles have increased in implementation to a variety of
applications ranging from high-efficiency electronics to targeted drug delivery. Recently …

Continuous flow microfluidic separation and processing of rare cells and bioparticles found in blood–A review

M Antfolk, T Laurell - Analytica chimica acta, 2017 - Elsevier
Rare cells in blood, such as circulating tumor cells or fetal cells in the maternal circulation,
posses a great prognostic or diagnostic value, or for the development of personalized …

Integrated “lab-on-a-chip” microfluidic systems for isolation, enrichment, and analysis of cancer biomarkers

S Surappa, P Multani, U Parlatan, PD Sinawang… - Lab on a Chip, 2023 - pubs.rsc.org
The liquid biopsy has garnered considerable attention as a complementary clinical tool for
the early detection, molecular characterization and monitoring of cancer over the past …