The X chromosome and X-linked variants have largely been ignored in genome-wide and
candidate association studies of infectious diseases due to the complexity of statistical …

Most human tumors are composed of genetically and phenotypically heterogeneous cancer
cell populations, which poses a major challenge for the clinical management of cancer …

Background Sex differences in obesity and related diseases are well established. Gonadal
hormones are a major determinant of these sex differences. However, sex differences in …

In female mammals, most genes on one X chromosome are silenced as a result of X-
chromosome inactivation,. However, some genes escape X-inactivation and are expressed …

Genomes 5 has been completely revised and updated. It is a thoroughly modern textbook
about genomes and how they are investigated. As with previous Genomes editions …

Differences between males and females in the optimal phenotype that is favoured by
selection can be resolved by the evolution of differential gene expression in the two sexes …

The theory of developmental programming suggests that diseases such as the metabolic
syndrome may be 'programmed'by exposure to adverse stimuli during early development …

Sexual dimorphism in body weight, fat distribution, and metabolic disease has been
attributed largely to differential effects of male and female gonadal hormones. Here, we …

Abstract Cytosolic free calcium ([Ca2+] cyt) is a ubiquitous signalling component in plant
cells. Numerous stimuli trigger sustained or transient elevations of [Ca2+] cyt that evoke …

Genomic imprinting, the parent-of-origin-specific silencing of a small proportion of genes,
introduces a paradoxical vulnerability of hemizygosity into the diploid mammalian genome …