[HTML][HTML] Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors
The complement system is a critical part of our innate immune response, and the terminal
products of this cascade, anaphylatoxins C3a and C5a, exert their physiological and …
products of this cascade, anaphylatoxins C3a and C5a, exert their physiological and …
Regulatory mechanism of miR-722 on C5aR1 and its functions against bacterial inflammation in half-smooth tongue sole (Cynoglossus semilaevis)
H Liu, S Tan, Y Chen, X Chen, X Liu, Z Li… - International Journal of …, 2023 - Elsevier
MicroRNAs (miRNAs) are small non-coding RNAs involved in various biological processes,
including immunity. Previously, we investigated the miRNAs of half-smooth tongue sole …
including immunity. Previously, we investigated the miRNAs of half-smooth tongue sole …
C5a drives the inflammatory response with bacterial dose effect by binding to C5aR1 in zebrafish infected with Aeromonas hydrophila
The complement system is essential to host defense, but its excessive activation caused by
severe pathogen invasion is a driving force in adverse inflammatory. The binding of …
severe pathogen invasion is a driving force in adverse inflammatory. The binding of …
Development of potent and selective agonists for complement C5a receptor 1 with in vivo activity
The anaphylatoxin C5a is a complement peptide associated with immune-related disorders.
C5a binds with equal potency to two GPCRs, C5aR1 and C5aR2. Multiple C5a peptide …
C5a binds with equal potency to two GPCRs, C5aR1 and C5aR2. Multiple C5a peptide …
TLQP-21 is a low potency partial C3aR activator on human primary macrophages
TLQP-21 is a 21-amino acid neuropeptide derived from the VGF precursor protein. TLQP-21
is expressed in the nervous system and neuroendocrine glands, and demonstrates …
is expressed in the nervous system and neuroendocrine glands, and demonstrates …
Manipulated C5aR1 over/down-expression associates with IL-6 expression during bacterial inflammation in half-smooth tongue sole (Cynoglossus semilaevis)
Z Wu, S Zang, W Wang, S Tan, Q Xu, X Chen… - Fish & Shellfish …, 2024 - Elsevier
The complement component 5a/complement component 5 receptor 1 (C5a/C5aR1) pathway
plays a crucial role in the onset and development of inflammation, but relevant studies in fish …
plays a crucial role in the onset and development of inflammation, but relevant studies in fish …
[HTML][HTML] Protocol for cell-based screening assay to measure ERK1/2 phosphorylation as a readout for complement receptor activation
The complement receptors C3aR and C5aR1 are promising therapeutic targets. Here, we
present a protocol to screen the effects of different agonists and antagonists on these …
present a protocol to screen the effects of different agonists and antagonists on these …
Adjuvants for Vaccines
JP Stewart, JA Vetro - Neuroimmune Pharmacology and Therapeutics, 2024 - Springer
This chapter highlights the general characteristics of pathogen-and host-derived adjuvants,
their advantages and disadvantages, and their contribution to adaptive immunity. An …
their advantages and disadvantages, and their contribution to adaptive immunity. An …
Structural insights into agonist-binding and activation of the human complement C3a receptor
The complement cascade is an integral part of innate immunity, and it plays a crucial role in
our body's innate immune response including combating microbial infections. Activation of …
our body's innate immune response including combating microbial infections. Activation of …