Reduced capacity to cognitively regulate emotional responses is a common impairment
across major neuropsychiatric disorders. Brain systems supporting one such strategy …

Corticostriatal circuits through the orbitofrontal cortex (OFC) play key roles in complex
human behaviors such as evaluation, affect regulation and reward-based decision-making …

Pornography consumption is highly prevalent, particularly among young adult males. For
some individuals, problematic pornography use (PPU) is a reason for seeking treatment …

The central and autonomic nervous systems can be defined by their anatomical, functional
and neurochemical characteristics, but neither functions in isolation. For example …

Adaptive decision making in dynamic environments requires multiple reinforcement-learning
steps that may be implemented by dissociable neural circuits. Here, we used a novel …

The habenula (Hb) is a central structure connecting forebrain to midbrain regions. This
microstructure regulates monoaminergic systems, notably dopamine and serotonin, and …

In this brief review, we describe current computational models of drug-use and addiction that
fall into 2 broad categories: mathematically based models that rely on computational …

Background The predominant view of chronic cocaine use maintains that it causes a broad
range of cognitive deficits. However, concerns about the possibly deleterious impact of …

Highlights•Computational psychiatry holds promise for mechanistic discovery in
addiction.•This approach captures latent factors driving behavioral differences from …

I argue that denial plays a central but insufficiently recognized role in addiction. The puzzle
inherent in addiction is why drug use persists despite negative consequences. The orthodox …