Structure, function, and pharmacology of glutamate receptor ion channels

KB Hansen, LP Wollmuth, D Bowie, H Furukawa… - Pharmacological …, 2021 - Elsevier
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Therapeutic potential of N-methyl-D-aspartate receptor modulators in psychiatry

JE Hanson, H Yuan, RE Perszyk, TG Banke… - …, 2024 - nature.com
Abstract N-methyl-D-aspartate (NMDA) receptors mediate a slow component of excitatory
synaptic transmission, are widely distributed throughout the central nervous system, and …

Structure, function, and allosteric modulation of NMDA receptors

KB Hansen, F Yi, RE Perszyk, H Furukawa… - Journal of General …, 2018 - rupress.org
NMDA-type glutamate receptors are ligand-gated ion channels that mediate a Ca2+-
permeable component of excitatory neurotransmission in the central nervous system (CNS) …

NMDARs mediate peripheral and central sensitization contributing to chronic orofacial pain

YJ Liu, YL Li, ZH Fang, HL Liao, YY Zhang… - Frontiers in Cellular …, 2022 - frontiersin.org
Peripheral and central sensitizations of the trigeminal nervous system are the main
mechanisms to promote the development and maintenance of chronic orofacial pain …

Excitatory GluN1/GluN3A glycine receptors (eGlyRs) in brain signaling

S Bossi, L Pizzamiglio, P Paoletti - Trends in Neurosciences, 2023 - cell.com
GluN3A is a glycine-binding subunit belonging to the NMDA receptor (NMDAR) family that
can assemble with GluN1 subunits to form unconventional NMDARs insensitive to glutamate …

[PDF][PDF] Structural insights into NMDA receptor pharmacology

C Zhou, N Tajima - Biochemical Society Transactions, 2023 - portlandpress.com
N-methyl-d-aspartate receptors (NMDARs) comprise a subfamily of ionotropic glutamate
receptors that form heterotetrameric ligand-gated ion channels and play fundamental roles …

De novo GRIN variants in NMDA receptor M2 channel pore‐forming loop are associated with neurological diseases

J Li, J Zhang, W Tang, RK Mizu, H Kusumoto… - Human …, 2019 - Wiley Online Library
N‐methyl‐D‐aspartate receptors (NMDARs) mediate slow excitatory postsynaptic
transmission in the central nervous system, thereby exerting a critical role in neuronal …

Functional and pharmacological properties of triheteromeric GluN1/2B/2D NMDA receptors

F Yi, S Bhattacharya, CM Thompson… - The Journal of …, 2019 - Wiley Online Library
Key points Triheteromeric NMDA receptors contain two GluN1 and two distinct GluN2
subunits and mediate excitatory neurotransmission in the CNS. Triheteromeric GluN1/2B/2D …

Structural biology of glutamate receptor ion channels: towards an understanding of mechanism

IH Greger, ML Mayer - Current Opinion in Structural Biology, 2019 - Elsevier
Ionotropic glutamate receptors (iGluRs) are tetrameric ion channels that mediate signal
transmission at neuronal synapses, where they contribute centrally to the postsynaptic …

[HTML][HTML] Synaptic Dysfunction by Mutations in GRIN2B: Influence of Triheteromeric NMDA Receptors on Gain-of-Function and Loss-of-Function Mutant Classification

M Elmasri, JS Lotti, W Aziz, OG Steele, E Karachaliou… - Brain Sciences, 2022 - mdpi.com
GRIN2B mutations are rare but often associated with patients having severe
neurodevelopmental disorders with varying range of symptoms such as intellectual …