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Scientific rationale for the use of α2A-adrenoceptor agonists in treating neuroinflammatory cognitive disorders
Neuroinflammatory disorders preferentially impair the higher cognitive and executive
functions of the prefrontal cortex (PFC). This includes such challenging disorders as …
functions of the prefrontal cortex (PFC). This includes such challenging disorders as …
Scientific rationale for the treatment of cognitive deficits from long COVID
Sustained cognitive deficits are a common and debilitating feature of “long COVID”, but
currently there are no FDA-approved treatments. The cognitive functions of the dorsolateral …
currently there are no FDA-approved treatments. The cognitive functions of the dorsolateral …
Localization of PDE4D, HCN1 channels, and mGluR3 in rhesus macaque entorhinal cortex may confer vulnerability in Alzheimer's disease
Alzheimer's disease cortical tau pathology initiates in the layer II cell clusters of entorhinal
cortex, but it is not known why these specific neurons are so vulnerable. Aging macaques …
cortex, but it is not known why these specific neurons are so vulnerable. Aging macaques …
[HTML][HTML] Stress and inflammation target dorsolateral prefrontal cortex function: Neural mechanisms underlying weakened cognitive control
MKP Joyce, S Uchendu, AFT Arnsten - Biological Psychiatry, 2024 - Elsevier
Most mental disorders involve dysfunction of the dorsolateral prefrontal cortex (dlPFC), a
recently evolved brain region that subserves working memory, abstraction and the thoughtful …
recently evolved brain region that subserves working memory, abstraction and the thoughtful …
Biomaterial strategies for regulating the neuroinflammatory response
AN Galindo, DAF Rubio, MH Hettiaratchi - Materials Advances, 2024 - pubs.rsc.org
Injury and disease in the central nervous system (CNS) can result in a dysregulated
inflammatory environment that inhibits the repair of functional tissue. Biomaterials present a …
inflammatory environment that inhibits the repair of functional tissue. Biomaterials present a …
Dendrimer-enabled targeted delivery attenuates glutamate excitotoxicity and improves motor function in a rabbit model of cerebral palsy
Glutamate carboxypeptidase II (GCPII), localized on the surface of astrocytes and activated
microglia, regulates extracellular glutamate concentration in the central nervous system …
microglia, regulates extracellular glutamate concentration in the central nervous system …
Chronic GCPII (glutamate‐carboxypeptidase‐II) inhibition reduces pT217Tau levels in the entorhinal and dorsolateral prefrontal cortices of aged macaques
Introduction Current approaches for treating sporadic Alzheimer's disease (sAD) focus on
removal of amyloid beta 1‐42 (Aβ1‐42) or phosphorylated tau, but additional strategies are …
removal of amyloid beta 1‐42 (Aβ1‐42) or phosphorylated tau, but additional strategies are …
Experimental approaches for altering the expression of Abeta‐degrading enzymes
DA Loeffler - Journal of neurochemistry, 2023 - Wiley Online Library
Cerebral clearance of amyloid β‐protein (Aβ) is decreased in early‐onset and late‐onset
Alzheimer's disease (AD). Aβ is cleared from the brain by enzymatic degradation and by …
Alzheimer's disease (AD). Aβ is cleared from the brain by enzymatic degradation and by …
Nanoscale imaging of pT217‐tau in aged rhesus macaque entorhinal and dorsolateral prefrontal cortex: Evidence of interneuronal trafficking and early‐stage …
INTRODUCTION Tau phosphorylated at threonine‐217 (pT217‐tau) is a novel fluid‐based
biomarker that predicts onset of Alzheimer's disease (AD) symptoms, but little is known …
biomarker that predicts onset of Alzheimer's disease (AD) symptoms, but little is known …
Neuropsychiatric Manifestations of COVID-19 Disease and Post Covid Syndrome: The Role of N Acetyl-cysteine and Acetyl-L-carnitine
T Barlattani, G Celenza, A Cavatassi… - Current …, 2024 - benthamdirect.com
COVID-19 is associated with neuropsychiatric symptoms, such as anosmia, anxiety,
depression, stress-related reactions, and psychoses. The illness can cause persistent …
depression, stress-related reactions, and psychoses. The illness can cause persistent …