The emergence and spread of multidrug-resistant strains of Mycobacterium tuberculosis
remains a major concern of tuberculosis control programmes worldwide, as treatment …

About a third of the human population is estimated to be infected with Mycobacterium
tuberculosis. The bacterium displays an excellent adaptability to survive within the host …

Escherichia coli-mycobacterium shuttle vectors are important tools for gene expression and
gene replacement in mycobacteria. However, most of the currently available vectors are …

Uracil DNA glycosylases (UDGs) are an important group of DNA repair enzymes, which
pioneer the base excision repair pathway by recognizing and excising uracil from DNA …

Applying antibiotics to susceptible bacterial cultures generates a minor population of
persisters that remain susceptible to antibiotics but can endure them for extended periods …

Mycobacterium tuberculosi s uracil-DNA glycosylase (Mt Ung), a key DNA repair enzyme,
represents an attractive target for the design of new antimycobacterial agents. However, only …

Tuberculosis caused by Mycobacterium tuberculosis (Mtb) is a significant public health
concern, exacerbated by the emergence of drug-resistant TB. To combat the host's dynamic …

Infectious diseases continue to be a major cause of human mortality. With the emergence of
drug resistance, diseases that were long thought to have been curable by antibiotics are …

About a third of the human population is estimated to be infected with Mycobacterium
tuberculosis. Emergence of drug resistant strains and the protracted treatment strategies …

Uracil DNA glycosylases are an important class of enzymes that hydrolyze the N-glycosidic
bond between the uracil base and the deoxyribose sugar to initiate uracil excision repair …