There is persuasive clinical and experimental evidence that macrophages promote cancer
initiation and malignant progression. During tumor initiation, they create an inflammatory …

The human transcriptome comprises> 80000 protein-coding transcripts and the estimated
number of proteins synthesized from these transcripts is in the range of 250000 to 1 million …

Neural crest cells are embryonic progenitors that generate numerous cell types in
vertebrates. With single-cell analysis, we show that mouse trunk neural crest cells become …

MicroRNAs (miRNAs) are short non-coding RNAs with key roles in cellular regulation. As
part of the fifth edition of the Functional Annotation of Mammalian Genome (FANTOM5) …

Regulated transcription controls the diversity, developmental pathways and spatial
organization of the hundreds of cell types that make up a mammal. Using single-molecule …

Post-translational histone modifications modulate chromatin activity to affect gene
expression. How chromatin states underlie lineage choice in single cells is relatively …

The FANTOM5 project investigates transcription initiation activities in more than 1,000
human and mouse primary cells, cell lines and tissues using CAGE. Based on manual …

Despite their importance, the molecular circuits that control the differentiation of naive T cells
remain largely unknown. Recent studies that reconstructed regulatory networks in …

The FANTOM web resource (http://fantom. gsc. riken. jp/) was developed to provide easy
access to the data produced by the FANTOM project. It contains the most complete and …

The three-dimensional arrangement of the human genome comprises a complex network of
structural and regulatory chromatin loops important for coordinating changes in transcription …