• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

We are witnessing a revolution in our understanding of primary aldosteronism (PA). In the
past 2 decades, we have learned that PA is a highly prevalent syndrome that is largely …

Primary aldosteronism (PA) due to a unilateral aldosterone-producing adenoma is a
common cause of hypertension. This can be cured, or greatly improved, by adrenal surgery …

Aldosterone-producing adenomas (APAs) are the commonest curable cause of
hypertension. Most have gain-of-function somatic mutations of ion channels or transporters …

Primary aldosteronism (PA) is the most common form of endocrine hypertension and is
characterized by inappropriately elevated aldosterone production via a renin-independent …

Primary aldosteronism is considered the commonest cause of secondary hypertension. In
affected individuals, aldosterone is produced in an at least partially autonomous fashion in …

Primary aldosteronism affects up to 10% of hypertensive patients and is responsible for
treatment resistance and increased cardiovascular risk. Here we perform a genome-wide …

Primary aldosteronism is the most common single cause of hypertension and is potentially
curable when only one adrenal gland is the culprit. The importance of primary aldosteronism …

Aldosterone is a major mineralocorticoid steroid hormone secreted by glomerulosa cells in
the adrenal cortex. It regulates a variety of physiological responses including those to …

Hypertension (HT) is a major cardiovascular risk factor that affects 10% to 40% of the
general population in an age-dependent manner. Detection of secondary forms of HT is …