Charting the genotype–phenotype map: lessons from the Drosophila melanogaster Genetic Reference Panel

TFC Mackay, W Huang - Wiley Interdisciplinary Reviews …, 2018 - Wiley Online Library
Understanding the genetic architecture (causal molecular variants, their effects, and
frequencies) of quantitative traits is important for precision agriculture and medicine and …

Shedding Light on Inter-Individual Variability of Olfactory Circuits in Drosophila

K Rihani, S Sachse - Frontiers in Behavioral Neuroscience, 2022 - frontiersin.org
Inter-individual differences in behavioral responses, anatomy or functional properties of
neuronal populations of animals having the same genotype were for a long time …

Stochasticity, individuality and behavior

K Honegger, B de Bivort - Current Biology, 2018 - cell.com
No two individuals are exactly alike. More than a simple platitude, this observation reflects
the fundamentally stochastic nature of biological systems. The term 'stochastic'describes …

Viruses in Laboratory Drosophila and Their Impact on Host Gene Expression

O Kuyateh, DJ Obbard - Viruses, 2023 - mdpi.com
Drosophila melanogaster has one of the best characterized antiviral immune responses
among invertebrates. However, relatively few easily transmitted natural virus isolates are …

The structure of behavioral variation within a genotype

Z Werkhoven, A Bravin, K Skutt-Kakaria, P Reimers… - Elife, 2021 - elifesciences.org
Individual animals vary in their behaviors. This is true even when they share the same
genotype and were reared in the same environment. Clusters of covarying behaviors …

Genome-Wide Association Study of Circadian Behavior in Drosophila melanogaster

ST Harbison, S Kumar, W Huang, LJ McCoy… - Behavior Genetics, 2019 - Springer
Circadian rhythms influence physiological processes from sleep–wake cycles to body
temperature and are controlled by highly conserved cycling molecules. Although the …

Transcriptome diversity is a systematic source of variation in RNA-sequencing data

PE García-Nieto, B Wang… - PLoS Computational …, 2022 - journals.plos.org
RNA sequencing has been widely used as an essential tool to probe gene expression.
While standard practices have been established to analyze RNA-seq data, it is still …

Using single‐plant‐omics in the field to link maize genes to functions and phenotypes

DF Cruz, S De Meyer, J Ampe, H Sprenger… - Molecular Systems …, 2020 - embopress.org
Most of our current knowledge on plant molecular biology is based on experiments in
controlled laboratory environments. However, translating this knowledge from the laboratory …

Widespread inter‐individual gene expression variability in Arabidopsis thaliana

S Cortijo, Z Aydin, S Ahnert… - Molecular systems biology, 2019 - embopress.org
A fundamental question in biology is how gene expression is regulated to give rise to a
phenotype. However, transcriptional variability is rarely considered although it could …

An Integrated Database for Exploring Alternative Promoters in Animals

F Xue, Y Yan, W **, H Zhu, Y Yang, Z Yu, X Xu… - Scientific Data, 2025 - nature.com
Alternative promoter (AP) events, as a major pre-transcriptional mechanism, can initiate
different transcription start sites to generate distinct mRNA isoforms and regulate their …