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Potential role of ANGPTL4 in the cross talk between metabolism and cancer through PPAR signaling pathway
The angiopoietin‐like 4 (ANGPTL4) protein belongs to a superfamily of secreted proteins
structurally related to factors modulating angiogenesis known as angiopoietins. At first …
structurally related to factors modulating angiogenesis known as angiopoietins. At first …
Angiopoietin-like 4: a decade of research
The past decade has seen a rapid development and increasing recognition of ANGPTL4
(angiopoietin-like 4) as a remarkably multifaceted protein that is involved in many metabolic …
(angiopoietin-like 4) as a remarkably multifaceted protein that is involved in many metabolic …
Short-chain fatty acids stimulate angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating peroxisome proliferator-activated receptor γ
Angiopoietin-like protein 4 (ANGPTL4/FIAF) has been proposed as a circulating mediator
between the gut microbiota and fat storage. Here, we show that transcription and secretion …
between the gut microbiota and fat storage. Here, we show that transcription and secretion …
Regulation of triglyceride metabolism by Angiopoietin-like proteins
Plasma triglyceride concentrations are determined by the balance between production of the
triglyceride-rich lipoproteins VLDL and chylomicrons in liver and intestine, and their …
triglyceride-rich lipoproteins VLDL and chylomicrons in liver and intestine, and their …
ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure
Brown adipose tissue (BAT) activation via cold exposure is increasingly scrutinized as a
potential approach to ameliorate cardio-metabolic risk. Transition to cold temperatures …
potential approach to ameliorate cardio-metabolic risk. Transition to cold temperatures …
ANGPTL4 Induction by Prostaglandin E2 under Hypoxic Conditions Promotes Colorectal Cancer Progression
Abstract Prostaglandin E2 (PGE2), the most abundant COX-2–derived prostaglandin found
in colorectal cancer, promotes tumor cell proliferation and survival via multiple signaling …
in colorectal cancer, promotes tumor cell proliferation and survival via multiple signaling …
Integrative and systemic approaches for evaluating PPARβ/δ (PPARD) function
The peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptors
that function as transcription factors regulating the expression of genes involved in cellular …
that function as transcription factors regulating the expression of genes involved in cellular …
Deregulation of PPARβ/δ target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment
The nuclear receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ) is a lipid
ligand-inducible transcription factor associated with macrophage polarization. However, its …
ligand-inducible transcription factor associated with macrophage polarization. However, its …
Angiopoietin-like proteins as therapeutic targets for cardiovascular disease: focus on lipid disorders
ABSTRACT Introduction: Angiopoietin-like (ANGPTL) proteins belong to a family of eight
secreted factors that are structurally related to proteins that modulate angiogenesi …
secreted factors that are structurally related to proteins that modulate angiogenesi …
Establishing the Role of PPARβ/δ in Carcinogenesis
The role of the nuclear hormone receptor peroxisome proliferator-activated receptor β/δ
(PPARβ/δ) in carcinogenesis is controversial because conflicting studies indicate that it both …
(PPARβ/δ) in carcinogenesis is controversial because conflicting studies indicate that it both …