Exploring tissue architecture using spatial transcriptomics

A Rao, D Barkley, D Pham, X Tan, B Balderson, J Xu, LF Grice… - Nature …, 2023 - nature.com
Spatial transcriptomics (ST) technologies generate multiple data types from biological
samples, namely gene expression, physical distance between data points, and/or tissue …

Molecularly defined and spatially resolved cell atlas of the whole mouse brain

M Zhang, X Pan, W Jung, AR Halpern, SW Eichhorn… - Nature, 2023 - nature.com
In mammalian brains, millions to billions of cells form complex interaction networks to enable
a wide range of functions. The enormous diversity and intricate organization of cells have …

Museum of spatial transcriptomics

L Moses, L Pachter - Nature methods, 2022 - nature.com
The function of many biological systems, such as embryos, liver lobules, intestinal villi, and
tumors, depends on the spatial organization of their cells. In the past decade, high …

Spatial-CUT&Tag: spatially resolved chromatin modification profiling at the cellular level

Y Deng, M Bartosovic, P Kukanja, D Zhang, Y Liu, G Su… - Science, 2022 - science.org
Spatial omics emerged as a new frontier of biological and biomedical research. Here, we
present spatial-CUT&Tag for spatially resolved genome-wide profiling of histone …

Systematic comparison of sequencing-based spatial transcriptomic methods

Y You, Y Fu, L Li, Z Zhang, S Jia, S Lu, W Ren, Y Liu… - Nature …, 2024 - nature.com
Recent developments of sequencing-based spatial transcriptomics (sST) have catalyzed
important advancements by facilitating transcriptome-scale spatial gene expression …

The role of m6A modification in the biological functions and diseases

X Jiang, B Liu, Z Nie, L Duan, Q **ong, Z **… - Signal transduction and …, 2021 - nature.com
Abstract N6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal
cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells …

Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays

A Chen, S Liao, M Cheng, K Ma, L Wu, Y Lai, X Qiu… - Cell, 2022 - cell.com
Spatially resolved transcriptomic technologies are promising tools to study complex
biological processes such as mammalian embryogenesis. However, the imbalance between …

HypoMap—a unified single-cell gene expression atlas of the murine hypothalamus

L Steuernagel, BYH Lam, P Klemm, GKC Dowsett… - Nature …, 2022 - nature.com
The hypothalamus plays a key role in coordinating fundamental body functions. Despite
recent progress in single-cell technologies, a unified catalog and molecular characterization …