Maternal obesity, diabetes during pregnancy and epigenetic mechanisms that influence the developmental origins of cardiometabolic disease in the offspring
Since 1980, global obesity has doubled, and the incidence of cardiometabolic diseases
such as type 2 diabetes and heart disease is also increasing. While genetic susceptibility …
such as type 2 diabetes and heart disease is also increasing. While genetic susceptibility …
Impact of Maternal Diet on the Epigenome during In Utero Life and the Developmental Programming of Diseases in Childhood and Adulthood
HS Lee - Nutrients, 2015 - mdpi.com
Exposure to environmental factors in early life can influence developmental processes and
long-term health in humans. Early life nutrition and maternal diet are well-known examples …
long-term health in humans. Early life nutrition and maternal diet are well-known examples …
[HTML][HTML] Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding
Maternal metabolic homeostasis exerts long-term effects on the offspring's health outcomes.
Here, we demonstrate that maternal high-fat diet (HFD) feeding during lactation predisposes …
Here, we demonstrate that maternal high-fat diet (HFD) feeding during lactation predisposes …
Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes
Z Vucetic, J Kimmel, K Totoki, E Hollenbeck… - …, 2010 - academic.oup.com
Maternal obesity during pregnancy increases the risk of obesity in the offspring. Obesity,
arising from an imbalance of energy intake and expenditure, can be driven by the ingestion …
arising from an imbalance of energy intake and expenditure, can be driven by the ingestion …
Enduring consequences of maternal obesity for brain inflammation and behavior of offspring
SD Bilbo, V Tsang - The FASEB Journal, 2010 - Wiley Online Library
Obesity is well characterized as a systemic inflammatory condition, and is also associated
with cognitive disruption, suggesting a link between the two. We assessed whether …
with cognitive disruption, suggesting a link between the two. We assessed whether …
Effects of maternal and paternal exercise on offspring metabolism
Maternal and paternal obesity and type 2 diabetes are recognized risk factors for the
development of metabolic dysfunction in offspring, even when the offspring follow a healthful …
development of metabolic dysfunction in offspring, even when the offspring follow a healthful …
A review of the impact of dietary intakes in human pregnancy on infant birthweight
Studies assessing maternal dietary intakes and the relationship with birthweight are
inconsistent, thus attempting to draw inferences on the role of maternal nutrition in …
inconsistent, thus attempting to draw inferences on the role of maternal nutrition in …
Maternal nutritional history predicts obesity in adult offspring independent of postnatal diet
Significant alterations in maternal nutrition may induce long‐term metabolic consequences
in offspring, in particular obesity and leptin and insulin resistance. Although maternal …
in offspring, in particular obesity and leptin and insulin resistance. Although maternal …
Effects of maternal surgical weight loss in mothers on intergenerational transmission of obesity
J Smith, K Cianflone, S Biron, FS Hould… - The Journal of …, 2009 - academic.oup.com
Background and Objectives: By studying cardiometabolic risk factors in children born after
maternal biliopancreatic diversion bariatric surgery (AMS) compared with those in children …
maternal biliopancreatic diversion bariatric surgery (AMS) compared with those in children …
Developmental origins of adult disease
SC Langley-Evans, S McMullen - Medical principles and practice, 2010 - karger.com
Variation in the quality or quantity of nutrients consumed during pregnancy can exert
permanent and powerful effects upon the develo** fetus. This programming of fetal …
permanent and powerful effects upon the develo** fetus. This programming of fetal …