The Hippo pathway and its downstream effectors, the transcriptional co-activators Yes-
associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) …

Cellular behavior is regulated by mechanical signals within the cellular microenvironment.
Additionally, changes of temperature, blood flow, and muscle contraction also affect cellular …

Reactive oxygen species (ROS) production in phagocytes is a major defense mechanism
against pathogens. However, the cellular self-protective mechanism against such potential …

Increasing evidence has demonstrated that drug resistance can be acquired in cancer cells
by kinase rewiring, which is an obstacle for efficient cancer therapy. However, it is …

Cellular senescence is a driver of various aging-associated disorders, including
osteoarthritis. Here, we identified a critical role for Yes-associated protein (YAP), a major …

The Hippo pathway is a central regulator of tissue development and homeostasis, and has
been reported to have a role during vascular development. Here we develop a …

Impaired angiogenesis and wound healing carry significant morbidity and mortality in
diabetic patients. Metabolic stress from hyperglycemia and elevated free fatty acids have …

Background and Aims Yes‐associated protein (YAP) plays an important role in
hepatocarcinogenesis, although the potential role of YAP in non‐neoplastic liver diseases …

Wnt/β-catenin signaling is highly conserved throughout metazoans, is required for numerous
essential events in development, and serves as a stem cell niche signal in many contexts …

YAP/TAZ, downstream transducers of the Hippo pathway, are powerful regulators of cancer
growth. How these factors control proliferation remains poorly defined. Here, we found that …