GABA A receptors are pentameric ligand-gated ion channels that mediate most fast
neuronal inhibition in the brain. In addition to their important physiological roles, they are …

Electron cryo-microscopy (cryo-EM) has revolutionized structure determination of membrane
proteins and holds great potential for structure-based drug discovery. Here we discuss the …

Type-A γ-aminobutyric (GABAA) receptors are ligand-gated chloride channels with a very
rich pharmacology. Some of their modulators, including benzodiazepines and general …

Glycine receptors (GlyRs) are pentameric,'Cys-loop'receptors that form chloride-permeable
channels and mediate fast inhibitory signalling throughout the central nervous system,. In …

Abstract Information processing in the brain depends on specialized organization of
neurotransmitter receptors and scaffolding proteins within the postsynaptic density …

The superfamily of pentameric ligand-gated ion channels (pLGICs) comprises key players in
electrochemical signal transduction across evolution, including historic model systems for …

Abstract Background and Purpose Epiberberine (EPI) is one of the most important
bioalkaloid found in the rhizome of Coptis chinensis, which has been observed to exhibit …

Neurosteroids (NS) are a class of steroids that are synthesized within the central nervous
system (CNS). Various NS can either enhance or inhibit CNS excitability and they play …

The pharmacological actions exerted by benzodiazepines are dependent on the discrete α
protein subunits of the γ-aminobutyric acid type A receptor (GABA AR). Recent …

Nicotinic acetylcholine receptors (nAChRs) modulate synaptic transmission in the nervous
system. These receptors have emerged as therapeutic targets in drug discovery for treating …