NAD+ has emerged as a vital cofactor that can rewire metabolism, activate sirtuins, and
maintain mitochondrial fitness through mechanisms such as the mitochondrial unfolded …

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in all living cells. It serves
both as a critical coenzyme for enzymes that fuel reduction-oxidation reactions, carrying …

Nicotinamide adenine dinucleotide (NAD), the cell's hydrogen carrier for redox enzymes, is
well known for its role in redox reactions. More recently, it has emerged as a signaling …

The conceptual evolution of nicotinamide adenine dinucleotide (NAD+) from being seen as
a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and …

Adult hippocampal neurogenesis is increased by antidepressants, and is required for some
of their behavioral effects. However, it remains unclear whether expanding the population of …

Traumatic brain injury (TBI) is the largest non-genetic, non-aging related risk factor for
Alzheimer's disease (AD). We report here that TBI induces tau acetylation (ac-tau) at sites …

Traumatic axonal injury (TAI) is an important pathoanatomical subgroup of traumatic brain
injury (TBI) and a major driver of mortality and functional impairment. Experimental models …

Peripheral polyneuropathy is a common and dose-limiting side effect of many important
chemotherapeutic agents. Most such neuropathies are characterized by early axonal …

Alzheimer's disease (AD) is the most common chronic neurodegenerative disease
worldwide. It causes cognitive dysfunction, such as aphasia and agnosia, and mental …

The P7C3 class of aminopropyl carbazole chemicals fosters the survival of neurons in a
variety of rodent models of neurodegeneration or nerve cell injury. To uncover its …