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Long non-coding RNAs: a new frontier in the study of human diseases
With the development of whole genome and transcriptome sequencing technologies, long
noncoding RNAs (lncRNAs) have received increased attention. Multiple studies indicate that …
noncoding RNAs (lncRNAs) have received increased attention. Multiple studies indicate that …
The emergence of lncRNAs in cancer biology
The discovery of numerous noncoding RNA (ncRNA) transcripts in species from yeast to
mammals has dramatically altered our understanding of cell biology, especially the biology …
mammals has dramatically altered our understanding of cell biology, especially the biology …
The human RNA-binding proteome and its dynamics during translational arrest
Proteins and RNA functionally and physically intersect in multiple biological processes,
however, currently no universal method is available to purify protein-RNA complexes. Here …
however, currently no universal method is available to purify protein-RNA complexes. Here …
TERT Promoter Mutations in Familial and Sporadic Melanoma
Cutaneous melanoma occurs in both familial and sporadic forms. We investigated a
melanoma-prone family through linkage analysis and high-throughput sequencing and …
melanoma-prone family through linkage analysis and high-throughput sequencing and …
53BP1 regulates heterochromatin through liquid phase separation
L Zhang, X Geng, F Wang, J Tang, Y Ichida… - Nature …, 2022 - nature.com
Human 53BP1 is primarily known as a key player in regulating DNA double strand break
(DSB) repair choice; however, its involvement in other biological process is less well …
(DSB) repair choice; however, its involvement in other biological process is less well …
Long non-coding RNAs and cancer: a new frontier of translational research?
Tiling array and novel sequencing technologies have made available the transcription
profile of the entire human genome. However, the extent of transcription and the function of …
profile of the entire human genome. However, the extent of transcription and the function of …
Comprehensive characterization of molecular differences in cancer between male and female patients
An individual's sex has been long recognized as a key factor affecting cancer incidence,
prognosis, and treatment responses. However, the molecular basis for sex disparities in …
prognosis, and treatment responses. However, the molecular basis for sex disparities in …
Basal-like breast cancer: a critical review
Recent gene expression profiling of breast cancer has identified specific subtypes with
clinical, biologic, and therapeutic implications. The basal-like group of tumors is …
clinical, biologic, and therapeutic implications. The basal-like group of tumors is …
Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing
Dicer is the enzyme that cleaves double-stranded RNA (dsRNA) into 21–25-nt-long species
responsible for sequence-specific RNA-induced gene silencing at the transcriptional, post …
responsible for sequence-specific RNA-induced gene silencing at the transcriptional, post …
X chromosomal abnormalities in basal-like human breast cancer
Sporadic basal-like cancers (BLC) are a distinct class of human breast cancers that are
phenotypically similar to BRCA1-associated cancers. Like BRCA1-deficient tumors, most …
phenotypically similar to BRCA1-associated cancers. Like BRCA1-deficient tumors, most …