▪ Abstract Cardiac hypertrophy is the heart's response to a variety of extrinsic and intrinsic
stimuli that impose increased biomechanical stress. While hypertrophy can eventually …

Calcium signaling activates the phosphatase calcineurin and induces movement of NFATc
proteins into the nucleus, where they cooperate with other proteins to form complexes on …

Down syndrome is the most common form of intellectual disability and results from one of the
most complex genetic perturbations that is compatible with survival, trisomy 21. The study of …

Cardiac hypertrophy is one of the main ways in which cardiomyocytes respond to
mechanical and neurohormonal stimuli. It enables myocytes to increase their work output …

Down syndrome is one of the major causes of mental retardation and congenital heart
malformations. Other common clinical features of Down syndrome include gastrointestinal …

Calcineurin (PP2B), a serine/threonine phosphatase controlled by cellular calcium, was
originally identified in extracts of mammalian brain. Within the past few years this …

The presence of melanin pigment within the iris is responsible for the visual impression of
human eye colouration with complex patterns also evident in this tissue, including Fuchs' …

Here we describe a small family of proteins, termed MCIP1 and MCIP2 (for myocyte-
enrichedcalcineurin interacting protein), that are expressed most abundantly in striated …

Aging is a common risk factor in neurodegenerative disorders. Investigating neuronal aging
in an isogenic background stands to facilitate analysis of the interplay between neuronal …

The protein phosphatase calcineurin mediates many cellular responses to calcium signals.
Using a genetic screen in yeast, we identified a new family of proteins conserved in fungi …