Comprehensive management of cardiovascular risk factors for adults with type 2 diabetes: a scientific statement from the American Heart Association

JJ Joseph, P Deedwania, T Acharya, D Aguilar… - Circulation, 2022 - Am Heart Assoc
Cardiovascular disease remains the leading cause of death in patients with diabetes.
Cardiovascular disease in diabetes is multifactorial, and control of the cardiovascular risk …

SGLT2 inhibitors: mechanisms of cardiovascular benefit beyond glycaemic control

MR Cowie, M Fisher - Nature Reviews Cardiology, 2020 - nature.com
Abstract Sodium–glucose cotransporter 2 (SGLT2) inhibitors are effective antidiabetic
therapies in patients with type 2 diabetes mellitus and are associated with improved …

Type 2 diabetes mellitus: a review of multi-target drugs

A Artasensi, A Pedretti, G Vistoli, L Fumagalli - Molecules, 2020 - mdpi.com
Diabetes Mellitus (DM) is a multi-factorial chronic health condition that affects a large part of
population and according to the World Health Organization (WHO) the number of adults …

Type 2 diabetes mellitus and heart failure: a scientific statement from the American Heart Association and the Heart Failure Society of America: this statement does not …

SM Dunlay, MM Givertz, D Aguilar, LA Allen, M Chan… - Circulation, 2019 - Am Heart Assoc
Type 2 diabetes mellitus is a risk factor for incident heart failure and increases the risk of
morbidity and mortality in patients with established disease. Secular trends in the …

Empagliflozin effects on pulmonary artery pressure in patients with heart failure: results from the EMBRACE-HF trial

ME Nassif, M Qintar, SL Windsor, R Jermyn… - Circulation, 2021 - Am Heart Assoc
Background: Sodium glucose cotransporter 2 inhibitors (SGLT2 inhibitors) prevent heart
failure (HF) hospitalizations in patients with type 2 diabetes and improve outcomes in those …

Dapagliflozin effects on biomarkers, symptoms, and functional status in patients with heart failure with reduced ejection fraction: the DEFINE-HF trial

ME Nassif, SL Windsor, F Tang, Y Khariton, M Husain… - Circulation, 2019 - Am Heart Assoc
Background: Outcome trials in patients with type 2 diabetes mellitus have demonstrated
reduced hospitalizations for heart failure (HF) with sodium-glucose co-transporter-2 …

Kluyveromyces marxianus: An emerging yeast cell factory for applications in food and biotechnology

A Karim, N Gerliani, M Aïder - International Journal of Food Microbiology, 2020 - Elsevier
Several yeasts, which are eukaryotic microorganisms, have long been used in different
industries due to their potential applications, both for fermentation and for the production of …

Clinical update: cardiovascular disease in diabetes mellitus: atherosclerotic cardiovascular disease and heart failure in type 2 diabetes mellitus–mechanisms …

CC Low Wang, CN Hess, WR Hiatt, AB Goldfine - Circulation, 2016 - Am Heart Assoc
Cardiovascular disease remains the principal cause of death and disability among patients
with diabetes mellitus. Diabetes mellitus exacerbates mechanisms underlying …

Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes

B Zinman, C Wanner, JM Lachin… - New england journal …, 2015 - Mass Medical Soc
Background The effects of empagliflozin, an inhibitor of sodium–glucose cotransporter 2, in
addition to standard care, on cardiovascular morbidity and mortality in patients with type 2 …

CV protection in the EMPA-REG OUTCOME trial: a “thrifty substrate” hypothesis

E Ferrannini, M Mark, E Mayoux - Diabetes care, 2016 - Am Diabetes Assoc
The striking and unexpected relative risk reductions in cardiovascular (CV) mortality (38%),
hospitalization for heart failure (35%), and death from any cause (32%) observed in the …