Background In early-onset severe hemolytic disease of the fetus and newborn (HDFN),
transplacental transfer of maternal antierythrocyte IgG alloantibodies causes fetal anemia …

Introduction: Hemolytic disease of the fetus and newborn (HDFN) remains a serious
pregnancy complication which can lead to severe fetal anemia, hydrops and perinatal death …

Introduction Hemolytic disease of the fetus and newborn (HDFN) is a condition caused by
maternal alloantibodies against fetal red blood cells (RBCs) that can cause severe morbidity …

Objective Maternal alloimmunization to fetal red‐blood‐cell antigens is a major cause of
fetal anemia, which can lead to hydrops and perinatal death if untreated. The cornerstone of …

Background Intrauterine transfusion for severe alloimmunization in pregnancy performed<
20 weeks' gestation is associated with a higher fetal death rate. Intravenous …

The main cause of fetal anemia is maternal red blood cell alloimmunization (AI). The search
of maternal antibodies by indirect antiglobulin test allows screening for AI during pregnancy …

Intravenous immunoglobulin (IVIG) was first administered to humans in the 1980s. The
mechanism of action of IVIG is still a subject of debate but the pharmacokinetics have been …

Background Prevention of pregnancy-related alloimmunization and the management of
hemolytic disease of the fetus and newborn (HDFN) has significantly improved over the past …

Objectives To assess the performance of middle cerebral artery peak systolic velocity (MCA‐
PSV) and of the expected daily decrease in fetal hemoglobin in determining the timing of …

Background: Alloimmunization to red blood cells (RBCs) may result in fetal anemia prior to
20 weeks gestation. The question as to whether early commencement of antenatal treatment …