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Two-photon calcium imaging of neuronal activity
In vivo two-photon calcium imaging (2PCI) is a technique used for recording neuronal
activity in the intact brain. It is based on the principle that, when neurons fire action …
activity in the intact brain. It is based on the principle that, when neurons fire action …
Making sense of astrocytic calcium signals—from acquisition to interpretation
Astrocytes functionally interact with neurons and with other brain cells. Although not
electrically excitable, astrocytes display a complex repertoire of intracellular Ca2+ signalling …
electrically excitable, astrocytes display a complex repertoire of intracellular Ca2+ signalling …
[HTML][HTML] Time and experience differentially affect distinct aspects of hippocampal representational drift
Hippocampal activity is critical for spatial memory. Within a fixed, familiar environment,
hippocampal codes gradually change over timescales of days to weeks—a phenomenon …
hippocampal codes gradually change over timescales of days to weeks—a phenomenon …
All-optical physiology resolves a synaptic basis for behavioral timescale plasticity
Learning has been associated with modifications of synaptic and circuit properties, but the
precise changes storing information in mammals have remained largely unclear. We …
precise changes storing information in mammals have remained largely unclear. We …
Neural circuit basis of placebo pain relief
Placebo effects are notable demonstrations of mind–body interactions,. During pain
perception, in the absence of any treatment, an expectation of pain relief can reduce the …
perception, in the absence of any treatment, an expectation of pain relief can reduce the …
A suite of transgenic driver and reporter mouse lines with enhanced brain-cell-type targeting and functionality
Modern genetic approaches are powerful in providing access to diverse cell types in the
brain and facilitating the study of their function. Here, we report a large set of driver and …
brain and facilitating the study of their function. Here, we report a large set of driver and …
Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus
Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by
environmental influences, and functionally implicated in behavioural responses to stress …
environmental influences, and functionally implicated in behavioural responses to stress …
[HTML][HTML] Controlling visually guided behavior by holographic recalling of cortical ensembles
Neurons in cortical circuits are often coactivated as ensembles, yet it is unclear whether
ensembles play a functional role in behavior. Some ensemble neurons have pattern …
ensembles play a functional role in behavior. Some ensemble neurons have pattern …
Dual-polarity voltage imaging of the concurrent dynamics of multiple neuron types
Genetically encoded fluorescent voltage indicators are ideally suited to reveal the
millisecond-scale interactions among and between targeted cell populations. However …
millisecond-scale interactions among and between targeted cell populations. However …
CaImAn an open source tool for scalable calcium imaging data analysis
Advances in fluorescence microscopy enable monitoring larger brain areas in-vivo with finer
time resolution. The resulting data rates require reproducible analysis pipelines that are …
time resolution. The resulting data rates require reproducible analysis pipelines that are …