The functions and regulation of the PTEN tumour suppressor: new modes and prospects
PTEN is a potent tumour suppressor, and its loss of function is frequently observed in both
heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase …
heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase …
Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies
Amplification of epidermal growth factor receptor (EGFR) and its active mutant EGFRvIII
occurs frequently in glioblastoma (GBM). While EGFR and EGFRvIII play critical roles in …
occurs frequently in glioblastoma (GBM). While EGFR and EGFRvIII play critical roles in …
Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR–STAT3 signalling
Activated EGFR signalling drives tumorigenicity in 50% of glioblastoma (GBM). However,
EGFR-targeting therapy has proven ineffective in treating patients with GBM, indicating that …
EGFR-targeting therapy has proven ineffective in treating patients with GBM, indicating that …
Paediatric and adult glioblastoma: multiform (epi) genomic culprits emerge
We have extended our understanding of the molecular biology that underlies adult
glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents …
glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents …
Role of glioblastoma stem cells in cancer therapeutic resistance: A perspective on antineoplastic agents from natural sources and chemical derivatives
ALV Alves, INF Gomes, AC Carloni, MN Rosa… - Stem Cell Research & …, 2021 - Springer
Glioblastoma (GBM) is the highest-grade form of glioma, as well as one of the most
aggressive types of cancer, exhibiting rapid cellular growth and highly invasive behavior …
aggressive types of cancer, exhibiting rapid cellular growth and highly invasive behavior …
Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma
As tumours evolve, the daughter cells of the initiating cell often become molecularly
heterogeneous and develop different functional properties and therapeutic vulnerabilities. In …
heterogeneous and develop different functional properties and therapeutic vulnerabilities. In …
Glioblastoma: from molecular pathology to targeted treatment
Glioblastoma (GBM) is one of the most lethal human cancers. Genomic analyses are
defining the molecular architecture of GBM, uncovering relevant subsets of patients whose …
defining the molecular architecture of GBM, uncovering relevant subsets of patients whose …
Epidermal growth factor receptor extracellular domain mutations in glioblastoma present opportunities for clinical imaging and therapeutic development
We explored the clinical and pathological impact of epidermal growth factor receptor (EGFR)
extracellular domain missense mutations. Retrospective assessment of 260 de novo …
extracellular domain missense mutations. Retrospective assessment of 260 de novo …
CXCL12/CXCR4 signal transduction in diseases and its molecular approaches in targeted-therapy
A Mousavi - Immunology Letters, 2020 - Elsevier
Chemokines are small molecules called “chemotactic cytokines” and regulate many
processes like leukocyte trafficking, homing of immune cells, maturation, cytoskeletal …
processes like leukocyte trafficking, homing of immune cells, maturation, cytoskeletal …
EGFR as a clinical marker in glioblastomas and other gliomas
Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein and a member of
the tyrosine kinase superfamily receptor. Gliomas are tumors originating from glial cells …
the tyrosine kinase superfamily receptor. Gliomas are tumors originating from glial cells …