Tight junction structure and function revisited
Tight junctions (TJs) are intercellular junctions critical for building the epithelial barrier and
maintaining epithelial polarity. The claudin family of membrane proteins play central roles in …
maintaining epithelial polarity. The claudin family of membrane proteins play central roles in …
[HTML][HTML] Target specific tight junction modulators
J Brunner, S Ragupathy, G Borchard - Advanced drug delivery reviews, 2021 - Elsevier
Intercellular tight junctions represent a formidable barrier against paracellular drug
absorption at epithelia (eg, nasal, intestinal) and the endothelium (eg, blood–brain barrier) …
absorption at epithelia (eg, nasal, intestinal) and the endothelium (eg, blood–brain barrier) …
How nanoparticles open the paracellular route of biological barriers: mechanisms, applications, and prospects
J Wu, Z Zhu, W Liu, Y Zhang, Y Kang, J Liu, C Hu… - ACS …, 2022 - ACS Publications
Biological barriers are essential physiological protective systems and obstacles to drug
delivery. Nanoparticles (NPs) can access the paracellular route of biological barriers, either …
delivery. Nanoparticles (NPs) can access the paracellular route of biological barriers, either …
Cell–cell interfaces as specialized compartments directing cell function
Cell–cell interfaces are found throughout multicellular organisms, from transient interactions
between motile immune cells to long-lived cell–cell contacts in epithelia. Studies of immune …
between motile immune cells to long-lived cell–cell contacts in epithelia. Studies of immune …
The epithelial cell leak pathway
The epithelial cell tight junction structure is the site of the transepithelial movement of solutes
and water between epithelial cells (paracellular permeability). Paracellular permeability can …
and water between epithelial cells (paracellular permeability). Paracellular permeability can …
The Bacillus cereus toxin alveolysin disrupts the intestinal epithelial barrier by inducing microtubule disorganization through CFAP100
S Sun, Z Xu, H Hu, M Zheng, L Zhang, W **e, L Sun… - Science …, 2023 - science.org
Bacillus cereus is a Gram-positive bacterium that mainly causes self-limiting emetic or
diarrheal illness but can also cause skin infections and bacteremia. Symptoms of B. cereus …
diarrheal illness but can also cause skin infections and bacteremia. Symptoms of B. cereus …
Emissions from modern engines induce distinct effects in human olfactory mucosa cells, depending on fuel and aftertreatment
Ultrafine particles (UFP) with a diameter of≤ 0.1 μm, are contributors to ambient air pollution
and derived mainly from traffic emissions, yet their health effects remain poorly …
and derived mainly from traffic emissions, yet their health effects remain poorly …
[HTML][HTML] Scaffolding proteins of vertebrate apical junctions: structure, functions and biophysics
Tight and adherens junctions are specialized sites of cell-cell interaction in epithelia and
endothelia, and are involved in barrier, adhesion, and signaling functions. These functions …
endothelia, and are involved in barrier, adhesion, and signaling functions. These functions …
Tricellulin secures the epithelial barrier at tricellular junctions by interacting with actomyosin
The epithelial cell sheet functions as a barrier to prevent invasion of pathogens. It is
necessary to eliminate intercellular gaps not only at bicellular junctions, but also at tricellular …
necessary to eliminate intercellular gaps not only at bicellular junctions, but also at tricellular …
Tight junction membrane proteins regulate the mechanical resistance of the apical junctional complex
Epithelia must be able to resist mechanical force to preserve tissue integrity. While
intercellular junctions are known to be important for the mechanical resistance of epithelia …
intercellular junctions are known to be important for the mechanical resistance of epithelia …