Tight junctions (TJs) are intercellular junctions critical for building the epithelial barrier and
maintaining epithelial polarity. The claudin family of membrane proteins play central roles in …

Tight junctions (TJs) are specialized regions of contact between cells of epithelial and
endothelial tissues that form selective semipermeable paracellular barriers that establish …

Intercellular tight junctions represent a formidable barrier against paracellular drug
absorption at epithelia (eg, nasal, intestinal) and the endothelium (eg, blood–brain barrier) …

Biological barriers are essential physiological protective systems and obstacles to drug
delivery. Nanoparticles (NPs) can access the paracellular route of biological barriers, either …

The gut mucosal epithelium is one of the largest organs in the body and plays a critical role
in regulating the crosstalk between the resident microbiome and the host. To this effect, the …

Cell–cell interfaces are found throughout multicellular organisms, from transient interactions
between motile immune cells to long-lived cell–cell contacts in epithelia. Studies of immune …

Intestinal epithelium functions as a tissue barrier to prevent interaction between the internal
compartment and the external milieu. Intestinal barrier function also determines epithelial …

The epithelial cell tight junction structure is the site of the transepithelial movement of solutes
and water between epithelial cells (paracellular permeability). Paracellular permeability can …

As biologics used in the clinic outpace the number of new small molecule drugs, an
important challenge for their efficacy and widespread use has emerged, namely tissue …

Tight and adherens junctions are specialized sites of cell-cell interaction in epithelia and
endothelia, and are involved in barrier, adhesion, and signaling functions. These functions …