Mass spectrometry imaging under ambient conditions

C Wu, AL Dill, LS Eberlin, RG Cooks… - Mass spectrometry …, 2013 - Wiley Online Library
Mass spectrometry imaging (MSI) has emerged as an important tool in the last decade and it
is beginning to show potential to provide new information in many fields owing to its unique …

Current state of the art of mass spectrometry-based metabolomics studies–a review focusing on wide coverage, high throughput and easy identification

Y Wang, S Liu, Y Hu, P Li, JB Wan - Rsc Advances, 2015 - pubs.rsc.org
Metabolomics aims at the comprehensive assessment of a wide range of endogenous
metabolites and attempts to identify and quantify the attractive metabolites in a given …

Ambient sampling/ionization mass spectrometry: applications and current trends

GA Harris, AS Galhena, FM Fernandez - Analytical chemistry, 2011 - ACS Publications
This biennial review discusses advances in the field of ambient sampling/ionization mass
spectrometry (“ambient MS” for short) in the period ranging from January 2009 to January …

In situ metabolic profiling of single cells by laser ablation electrospray ionization mass spectrometry

B Shrestha, A Vertes - Analytical chemistry, 2009 - ACS Publications
Depending on age, phase in the cell cycle, nutrition, and environmental factors, individual
cells exhibit large metabolic diversity. To explore metabolic variations in cell populations …

Simultaneous imaging of small metabolites and lipids in rat brain tissues at atmospheric pressure by laser ablation electrospray ionization mass spectrometry

P Nemes, AS Woods, A Vertes - Analytical chemistry, 2010 - ACS Publications
Atmospheric pressure imaging mass spectrometry is a rapidly expanding field that offers
advantages in the ability to study biological systems in their native condition, simplified …

Three-dimensional imaging of metabolites in tissues under ambient conditions by laser ablation electrospray ionization mass spectrometry

P Nemes, AA Barton, A Vertes - Analytical Chemistry, 2009 - ACS Publications
Three-dimensional (3D) imaging of molecular distributions offers insight into the correlation
between biochemical processes and the spatial organization of a biological tissue …

Ambient mass spectrometry in metabolomics

CS Clendinen, ME Monge, FM Fernández - Analyst, 2017 - pubs.rsc.org
Since the introduction of desorption electrospray ionization (DESI) mass spectrometry (MS),
ambient MS methods have seen increased use in a variety of fields from health to food …

Spatially resolved in vivo plant metabolomics by laser ablation-based mass spectrometry imaging (MSI) techniques: LDI-MSI and LAESI

B Bartels, A Svatoš - Frontiers in Plant Science, 2015 - frontiersin.org
This short review aims to summarize the current developments and applications of mass
spectrometry-based methods for in situ profiling and imaging of plants with minimal or no …

Direct analysis of lipids and small metabolites in mouse brain tissue by AP IR-MALDI and reactive LAESI mass spectrometry

B Shrestha, P Nemes, J Nazarian, Y Hathout… - Analyst, 2010 - pubs.rsc.org
Ambient analysis of metabolites and lipids from unprocessed animal tissue by mass
spectrometry remains a challenge. The utility of the two novel ambient ionization techniques …

Laser-based ambient mass spectrometry

SC Cheng, C Shiea, YL Huang, CH Wang, YT Cho… - Analytical …, 2017 - pubs.rsc.org
Laser has been an important tool in mass spectrometry due to its multifunctional capability of
desorption and ionization. However, the ionization efficiency by irradiating laser beams on a …