Key principles and methods for studying the endocytosis of biological and nanoparticle therapeutics
Endocytosis is a critical step in the process by which many therapeutic nanomedicines reach
their intracellular targets. Our understanding of cellular uptake mechanisms has developed …
their intracellular targets. Our understanding of cellular uptake mechanisms has developed …
Endocytosis in cancer and cancer therapy
Endocytosis is a complex process whereby cell surface proteins, lipids and fluid from the
extracellular environment are packaged, sorted and internalized into cells. Endocytosis is …
extracellular environment are packaged, sorted and internalized into cells. Endocytosis is …
Harnessing natural killer cells for cancer immunotherapy: dispatching the first responders
NA Maskalenko, D Zhigarev… - Nature reviews Drug …, 2022 - nature.com
Natural killer (NK) cells have crucial roles in the innate immunosurveillance of cancer and
viral infections. They are 'first responders' that can spontaneously recognize abnormal cells …
viral infections. They are 'first responders' that can spontaneously recognize abnormal cells …
Chemo-physical Strategies to Advance the in Vivo Functionality of Targeted Nanomedicine: The Next Generation
The past few decades have witnessed an evolution of nanomedicine from biologically inert
entities to more smart systems, aimed at advancing in vivo functionality. However, we should …
entities to more smart systems, aimed at advancing in vivo functionality. However, we should …
How can we use the endocytosis pathways to design nanoparticle drug-delivery vehicles to target cancer cells over healthy cells?
Targeted drug delivery in cancer typically focuses on maximising the endocytosis of drugs
into the diseased cells. However, there has been less focus on exploiting the differences in …
into the diseased cells. However, there has been less focus on exploiting the differences in …
HER2-Mediated Internalization of Cytotoxic Agents in ERBB2 Amplified or Mutant Lung Cancers
Amplification of and oncogenic mutations in ERBB2, the gene encoding the HER2 receptor
tyrosine kinase, promote receptor hyperactivation and tumor growth. Here we demonstrate …
tyrosine kinase, promote receptor hyperactivation and tumor growth. Here we demonstrate …
N6-methyladenosine regulated FGFR4 attenuates ferroptotic cell death in recalcitrant HER2-positive breast cancer
Y Zou, S Zheng, X ** pathway in resting cells but additional …