Pituitary-tumor endocrinopathies

S Melmed - New England Journal of Medicine, 2020 - Mass Medical Soc
Pituitary-Tumor Endocrinopathies Pituitary adenomas account for about 15% of intracranial
tumors. Clinical manifestations of disease reflect the oversecretion of the involved hormone …

Acromegaly

S Melmed - New England Journal of Medicine, 2006 - Mass Medical Soc
Pituitary tumors account for about 15% of primary intracranial neoplasms. Proliferation of
pituitary cells, which secrete hormones, may result in a spectrum of endocrine symptoms …

Acromegaly: an endocrine society clinical practice guideline

L Katznelson, ER Laws Jr, S Melmed… - The Journal of …, 2014 - academic.oup.com
Objective: The aim was to formulate clinical practice guidelines for acromegaly. Participants:
The Task Force included a chair selected by the Endocrine Society Clinical Guidelines …

A consensus on the diagnosis and treatment of acromegaly comorbidities: an update

A Giustina, A Barkan, A Beckers… - The Journal of …, 2020 - academic.oup.com
Objective The aim of the Acromegaly Consensus Group was to revise and update the
consensus on diagnosis and treatment of acromegaly comorbidities last published in 2013 …

Systemic complications of acromegaly and the impact of the current treatment landscape: an update

MR Gadelha, L Kasuki, DST Lim… - Endocrine reviews, 2019 - academic.oup.com
Acromegaly is a chronic systemic disease with many complications and is associated with
increased mortality when not adequately treated. Substantial advances in acromegaly …

Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects

N Møller, JOL Jørgensen - Endocrine reviews, 2009 - academic.oup.com
In evolutionary terms, GH and intracellular STAT 5 signaling is a very old regulatory system.
Whereas insulin dominates periprandially, GH may be viewed as the primary anabolic …

Complications of acromegaly: cardiovascular, respiratory and metabolic comorbidities

R Pivonello, RS Auriemma, LFS Grasso, C Pivonello… - Pituitary, 2017 - Springer
Acromegaly is associated with an enhanced mortality, with cardiovascular and respiratory
complications representing not only the most frequent comorbidities but also two of the main …

Diagnosis and treatment of acromegaly: an update

N Ershadinia, NA Tritos - Mayo Clinic Proceedings, 2022 - Elsevier
Acromegaly is typically caused by a growth hormone–secreting pituitary adenoma, driving
excess secretion of insulin-like growth factor 1. Acromegaly may result in a variety of …

Acromegaly

S Melmed - The pituitary, 2017 - Elsevier
Acromegaly is caused by excess growth hormone (GH) secretion emanating from a
somatotroph adenoma. High GH and Insulin-like growth factor-1 (IGF-1) levels lead to acral …

Acromegaly

A Ben-Shlomo, S Melmed - Endocrinology and metabolism clinics of North …, 2008 - Elsevier
Acromegaly is a rare disease caused by growth hormone hypersecretion, mostly from a
pituitary adenoma, driving insulin-like growth factor 1 overproduction. Manifestations include …