Approximately 5% of the world-wide population is affected by autoimmune diseases.
Overall, autoimmune diseases are still difficult to treat, impose a high burden on patients …

Autoimmune diseases (AIDs) are the consequence of a breach in immune tolerance,
leading to the inability to sufficiently differentiate between self and non-self. Immune …

For a long time, viruses have been shown to modify the clinical picture of several
autoimmune diseases, including type 1 diabetes (T1D), systemic lupus erythematosus …

Abstract Coronavirus disease 2019 (COVID‐19) is still propagating a year after the start of
the pandemic. Besides the complications patients face during the COVID‐19 disease period …

Clonal selection theory proposed that individual T cells are specific for a single peptide–
MHC antigen. However, the repertoire of αβ T cell receptors (TCRs) is dwarfed by the vast …

A variety of mechanisms have been suggested as the means by which infections can initiate
and/or exacerbate autoimmune diseases. One mechanism is molecular mimicry, where a …

Herpes simplex virus type 1 (HSV) keratitis is a leading cause of infectious blindness.
Clinical disease occurs variably throughout the cornea from epithelium to endothelium and …

In rheumatoid arthritis (RA), immunological triggers at mucosal sites, such as the gut
microbiota, may promote autoimmunity that affects joints. Here, we used discovery-based …

Autoimmune diseases, with the exception of rheumatoid arthritis and autoimmune thyroiditis,
are individually rare, but together they affect approximately 5 percent of the population in …

Cell-mediated (type-1) immunity is necessary for immune protection against most
intracellular pathogens and, when excessive, can mediate organ-specific autoimmune …