Dysregulation of mRNA translation is a frequent feature of neoplasia. Many oncogenes and
tumour suppressors affect the translation machinery, making aberrant translation a …

The natural amino acid hypusine (N δ-4-amino-2-hydroxybutyl (lysine)) is derived from the
polyamine spermidine, and occurs only in a single family of cellular proteins, eukaryotic …

The eukaryotic initiation factor eIF5A is a translation factor that, unusually, has been
assigned functions in both initiation and elongation. Additionally, it is implicated in …

A virus minimally contains a nucleic acid genome packaged by a protein coat. The genome
and capsid together are known as the nucleocapsid, which has an envelope containing a …

Protein synthesis is a vital cellular process that regulates growth and metabolism. It is
controlled via signaling networks in response to environmental changes, including the …

Abstract Hypusine [N ε-(4-amino-2-hydroxybutyl) lysine] is a derivative of lysine that is
formed post-translationally in the eukaryotic initiation factor 5A (eIF5A). Its occurrence at a …

As a convergent mechanism downstream of most oncogenic signals, control of mRNA
translation has emerged as a key driver in establishing and tuning gene expression at …

Protein synthesis can be segmented into distinct phases comprising mRNA translation
initiation, elongation, and termination. Translation initiation is a highly regulated and rate …

Abstract Zinc-finger protein 331 (ZNF331), a Kruppel-associated box zinc-finger protein
gene, was identified as a putative tumor suppressor in our previous study. However, the role …

The eukaryotic initiation factor 5A (eIF5A), which is highly conserved throughout evolution,
has the unique characteristic of post-translational activation through hypusination. This …