In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the
nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize …

The spatial organization of the genome into compartments and topologically associated
domains can have an important role in the regulation of gene expression. But could gene …

Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the
nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm …

Nuclear organization has been implicated in regulating gene activity. Recently, large
developmentally regulated regions of the genome dynamically associated with the nuclear …

The vast diversity of neurons and glia of the CNS is generated from a small, heterogeneous
population of progenitors that undergo transcriptional changes during development to …

Progenitor cells differentiate into specialized cell types through coordinated expression of
lineage-specific genes and modification of complex chromatin configurations. We …

A small pool of neural progenitors generates the vast diversity of cell types in the CNS.
Spatial patterning specifies progenitor identity, followed by temporal patterning within …

Nuclear lamins are type V intermediate filament proteins that polymerize into complex
filamentous meshworks at the nuclear periphery and in less structured forms throughout the …

In the Drosophila optic lobes, the medulla processes visual information coming from inner
photoreceptors R7 and R8 and from lamina neurons. It contains approximately 40,000 …

Genome-wide molecular studies have provided new insights into the organization of nuclear
chromatin by revealing the presence of chromatin domains of differing transcriptional …