[HTML][HTML] Lysosomal microautophagy: an emerging dimension in mammalian autophagy
Autophagy is a self-catabolic process through which cellular components are delivered to
lysosomes for degradation. There are three types of autophagy, ie, macroautophagy …
lysosomes for degradation. There are three types of autophagy, ie, macroautophagy …
STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes
Stimulator of interferon genes (STING) is essential for the type I interferon response against
a variety of DNA pathogens. Upon emergence of cytosolic DNA, STING translocates from the …
a variety of DNA pathogens. Upon emergence of cytosolic DNA, STING translocates from the …
Crosstalk between RNA viruses and DNA sensors: Role of the cGAS‐STING signalling pathway
Despite only comprising half of all known viral species, RNA viruses are disproportionately
responsible for many of the worst epidemics in human history, including outbreaks of …
responsible for many of the worst epidemics in human history, including outbreaks of …
Single-molecule localization microscopy reveals STING clustering at the trans-Golgi network through palmitoylation-dependent accumulation of cholesterol
H Kemmoku, K Takahashi, K Mukai, T Mori… - Nature …, 2024 - nature.com
Stimulator of interferon genes (STING) is critical for the type I interferon response to
pathogen-or self-derived DNA in the cytosol. STING may function as a scaffold to activate …
pathogen-or self-derived DNA in the cytosol. STING may function as a scaffold to activate …
A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity
M Zhao, Y Zhang, L Qiang, Z Lu, Z Zhao, Y Fu, B Wu… - Cell Reports, 2023 - cell.com
The regulation of antiviral immunity is crucial in maintaining host immune homeostasis, a
process that involves dynamic modulations of host organelles. The Golgi apparatus is …
process that involves dynamic modulations of host organelles. The Golgi apparatus is …
The critical roles of STING in mitochondrial homeostasis
S Zou, B Wang, K Yi, D Su, Y Chen, N Li… - Biochemical …, 2024 - Elsevier
The stimulator of interferon genes (STING) is a crucial signaling hub in the immune system's
antiviral and antimicrobial defense by detecting exogenous and endogenous DNA. The …
antiviral and antimicrobial defense by detecting exogenous and endogenous DNA. The …
The activation of the adaptor protein STING depends on its interactions with the phospholipid PI4P
RD Luteijn, SR van Terwisga, JE Ver Eecke, L Onia… - Science …, 2024 - science.org
Activation of the endoplasmic reticulum (ER)–resident adaptor protein STING, a component
of a cytosolic DNA–sensing pathway, induces the transcription of genes encoding type I …
of a cytosolic DNA–sensing pathway, induces the transcription of genes encoding type I …
Membrane traffic governs the STING inflammatory signalling
T Taguchi - The Journal of Biochemistry, 2023 - academic.oup.com
The cGAS-STING innate immune pathway has recently emerged as a critical driver of
inflammation in a variety of settings, such as virus infection, cellular stress and tissue …
inflammation in a variety of settings, such as virus infection, cellular stress and tissue …
[HTML][HTML] Early signs of neurodegenerative diseases: Possible mechanisms and targets for Golgi stress
M Liu, Y Duan, J Dong, K Zhang, X **, M Gao… - Biomedicine & …, 2024 - Elsevier
The Golgi apparatus plays a crucial role in mediating the modification, transport, and sorting
of intracellular proteins and lipids. The morphological changes occurring in the Golgi …
of intracellular proteins and lipids. The morphological changes occurring in the Golgi …
The activity of disease-causative STING variants can be suppressed by wild-type STING through heterocomplex formation
Stimulator of interferon genes (STING) is essential for the type I interferon response induced
by microbial DNA from viruses or self-DNA from mitochondria/nuclei. Recently, gain-of …
by microbial DNA from viruses or self-DNA from mitochondria/nuclei. Recently, gain-of …