[HTML][HTML] Lysosomal microautophagy: an emerging dimension in mammalian autophagy

Y Kuchitsu, T Taguchi - Trends in Cell Biology, 2024 - cell.com
Autophagy is a self-catabolic process through which cellular components are delivered to
lysosomes for degradation. There are three types of autophagy, ie, macroautophagy …

STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes

Y Kuchitsu, K Mukai, R Uematsu, Y Takaada… - Nature Cell …, 2023 - nature.com
Stimulator of interferon genes (STING) is essential for the type I interferon response against
a variety of DNA pathogens. Upon emergence of cytosolic DNA, STING translocates from the …

Crosstalk between RNA viruses and DNA sensors: Role of the cGAS‐STING signalling pathway

YM Fan, YL Zhang, H Luo… - Reviews in medical …, 2022 - Wiley Online Library
Despite only comprising half of all known viral species, RNA viruses are disproportionately
responsible for many of the worst epidemics in human history, including outbreaks of …

Single-molecule localization microscopy reveals STING clustering at the trans-Golgi network through palmitoylation-dependent accumulation of cholesterol

H Kemmoku, K Takahashi, K Mukai, T Mori… - Nature …, 2024 - nature.com
Stimulator of interferon genes (STING) is critical for the type I interferon response to
pathogen-or self-derived DNA in the cytosol. STING may function as a scaffold to activate …

A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity

M Zhao, Y Zhang, L Qiang, Z Lu, Z Zhao, Y Fu, B Wu… - Cell Reports, 2023 - cell.com
The regulation of antiviral immunity is crucial in maintaining host immune homeostasis, a
process that involves dynamic modulations of host organelles. The Golgi apparatus is …

The critical roles of STING in mitochondrial homeostasis

S Zou, B Wang, K Yi, D Su, Y Chen, N Li… - Biochemical …, 2024 - Elsevier
The stimulator of interferon genes (STING) is a crucial signaling hub in the immune system's
antiviral and antimicrobial defense by detecting exogenous and endogenous DNA. The …

The activation of the adaptor protein STING depends on its interactions with the phospholipid PI4P

RD Luteijn, SR van Terwisga, JE Ver Eecke, L Onia… - Science …, 2024 - science.org
Activation of the endoplasmic reticulum (ER)–resident adaptor protein STING, a component
of a cytosolic DNA–sensing pathway, induces the transcription of genes encoding type I …

Membrane traffic governs the STING inflammatory signalling

T Taguchi - The Journal of Biochemistry, 2023 - academic.oup.com
The cGAS-STING innate immune pathway has recently emerged as a critical driver of
inflammation in a variety of settings, such as virus infection, cellular stress and tissue …

[HTML][HTML] Early signs of neurodegenerative diseases: Possible mechanisms and targets for Golgi stress

M Liu, Y Duan, J Dong, K Zhang, X **, M Gao… - Biomedicine & …, 2024 - Elsevier
The Golgi apparatus plays a crucial role in mediating the modification, transport, and sorting
of intracellular proteins and lipids. The morphological changes occurring in the Golgi …

The activity of disease-causative STING variants can be suppressed by wild-type STING through heterocomplex formation

R Shindo, Y Kuchitsu, K Mukai… - Frontiers in Cell and …, 2022 - frontiersin.org
Stimulator of interferon genes (STING) is essential for the type I interferon response induced
by microbial DNA from viruses or self-DNA from mitochondria/nuclei. Recently, gain-of …