Although genetic susceptibility explains the clustering of multiple sclerosis (MS) cases within
families and the sharp decline in risk with increasing genetic distance, it cannot fully explain …

Compelling evidence indicates that Epstein Barr virus (EBV) infection is a prerequisite for
multiple sclerosis (MS). The disease may arise from a complex interplay between latent EBV …

SUMMARY Human herpesvirus 6 (HHV-6) is a betaherpesvirus that is closely related to
human cytomegalovirus. It was discovered in 1986, and HHV-6 literature has expanded …

ContextEpidemiological studies suggest an association between infection with Epstein-Barr
virus (EBV) and risk of multiple sclerosis (MS). ObjectiveTo determine whether elevation in …

Roles for viral infections and aberrant immune responses in driving localized
neuroinflammation and neurodegeneration in multiple sclerosis (MS) are the focus of …

Recent research indicates that multiple sclerosis is preceded by a prodromal phase with
elevated levels of serum neurofilament light chain (sNfL), a marker of axonal injury. The …

ContextInfection with common viruses, particularly Epstein-Barr virus (EBV), has been
postulated to contribute to the pathobiology of multiple sclerosis (MS). Detailed virological …

Human herpesvirus (HHV)-6A or HHV-6B involvement in multiple sclerosis (MS) etiology
has remained controversial mainly due to the lack of serological methods that can …

ContextThe “hygiene hypothesis” has implicated sibship as a marker of infection load during
early life and suggests that exposure or reexposure to infections can influence the …

Background and purpose Infections with human herpesvirus 6A (HHV‐6A) and Epstein–Barr
virus (EBV) have been linked to multiple sclerosis (MS) development. For EBV, late infection …