The silent information regulator sirtuin 1 (SIRT1) protein, a highly conserved NAD+-
dependent deacetylase belonging to the sirtuin family, is a post-translational regulator that …

Sirtuins such as SIRT1 are conserved protein NAD+-dependent deacylases and thus their
function is intrinsically linked to cellular metabolism. Over the past two decades …

Down syndrome (DS) is caused by trisomy of human chromosome 21 (Hsa21). DS is a gene
dosage disorder that results in multiple phenotypes including congenital heart defects. This …

Trisomy 21, the presence of a supernumerary chromosome 21, results in a collection of
clinical features commonly known as Down syndrome (DS). DS is among the most …

Since the beginning of the century, the mammalian sirtuin protein family (comprising SIRT1–
SIRT7) has received much attention for its regulatory role, mainly in metabolism and ageing …

Protein lysine acetylation is an important posttranslational modification that regulates
numerous biological processes. Targeting lysine acetylation regulatory factors, such as …

Dual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) is a conserved
protein kinase that plays essential roles in various biological processes. It is located in the …

Sirtuins are a class of NAD+-dependent deacetylases having beneficial health effects. This
extensive review describes the numerous intracellular actions of the seven mammalian …

SIRT1, an NAD‐dependent deacetylase, plays a role in regulation of autophagy. SIRT1
increases mitochondrial function and reduces oxidative stress, and has been linked to age …

Chronic inflammation is a major contributing factor in the pathogenesis of many age-
associated diseases. One central protein that regulates inflammation is NF-κB, the activity of …