Amyloid β protein and Alzheimer's disease: When computer simulations complement experimental studies
Alzheimer's disease (AD) challenges our society with an annual estimated cost of $1.08
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …
Amyloid β-protein oligomers and Alzheimer's disease
EY Hayden, DB Teplow - Alzheimer's research & therapy, 2013 - Springer
The oligomer cascade hypothesis, which states that oligomers are the initiating pathologic
agents in Alzheimer's disease, has all but supplanted the amyloid cascade hypothesis …
agents in Alzheimer's disease, has all but supplanted the amyloid cascade hypothesis …
Amyloid-β peptide dimers undergo a random coil to β-sheet transition in the aqueous phase but not at the neuronal membrane
Mounting evidence suggests that the neuronal cell membrane is the main site of oligomer-
mediated neuronal toxicity of amyloid-β peptides in Alzheimer's disease. To gain a detailed …
mediated neuronal toxicity of amyloid-β peptides in Alzheimer's disease. To gain a detailed …
Aβ42 and Aβ40: similarities and differences
The abnormal accumulation of amyloid‐β (Aβ) peptide in the brain is one of the most
important hallmarks of Alzheimer's disease. Aβ is an aggregation‐prone and toxic …
important hallmarks of Alzheimer's disease. Aβ is an aggregation‐prone and toxic …
Pathways of amyloid-β aggregation depend on oligomer shape
One of the main research topics related to Alzheimer's disease is the aggregation of the
amyloid-β peptide, which was shown to follow different pathways for the two major alloforms …
amyloid-β peptide, which was shown to follow different pathways for the two major alloforms …
Molecular Mechanism of the Inhibition of EGCG on the Alzheimer Aβ1–42 Dimer
T Zhang, J Zhang, P Derreumaux… - The journal of physical …, 2013 - ACS Publications
Growing evidence supports that amyloid β (Aβ) oligomers are the major causative agents
leading to neural cell death in Alzheimer's disease. The polyphenol (−)-epigallocatechin …
leading to neural cell death in Alzheimer's disease. The polyphenol (−)-epigallocatechin …
The Toxicity of Amyloid β Oligomers
In this review, we elucidate the mechanisms of A β oligomer toxicity which may contribute to
Alzheimer's disease (AD). In particular, we discuss on the interaction of A β oligomers with …
Alzheimer's disease (AD). In particular, we discuss on the interaction of A β oligomers with …
High-resolution structures of the amyloid-β 1–42 dimers from the comparison of four atomistic force fields
VH Man, PH Nguyen… - The Journal of Physical …, 2017 - ACS Publications
The dimer of the amyloid-β peptide Aβ of 42 residues is the smallest toxic species in
Alzheimer's disease, but its equilibrium structures are unknown. Here we determined the …
Alzheimer's disease, but its equilibrium structures are unknown. Here we determined the …
Differences in the free energies between the excited states of Aβ40 and Aβ42 monomers encode their aggregation propensities
D Chakraborty, JE Straub… - Proceedings of the …, 2020 - National Acad Sciences
The early events in the aggregation of the intrinsically disordered peptide, amyloid-β (A β),
involve transitions from the disordered free energy ground state to assembly-competent …
involve transitions from the disordered free energy ground state to assembly-competent …
[HTML][HTML] Amyloid β interaction with model cell membranes–What are the toxicity-defining properties of amyloid β?
Disruption of the neuronal membrane by toxic amyloid β oligomers is hypothesized to be the
major event associated with Alzheimer's disease's neurotoxicity. Misfolding of amyloid β is …
major event associated with Alzheimer's disease's neurotoxicity. Misfolding of amyloid β is …