We discuss the genetic, demographic, and selective forces that are likely to be at play in
restricting observed levels of DNA sequence variation in natural populations to a much …

The relative evolutionary roles of adaptive and non-adaptive processes remain a central
question in population genetics. Resolution of this debate has been difficult as an …

Selection on codon usage bias is well documented in a number of microorganisms. Whether
codon usage is also generally shaped by natural selection in large organisms, despite their …

Under the neutral theory, genetic diversity is expected to increase with population size.
While comparative analyses have consistently failed to find strong relationships between …

Current procedures for inferring population history generally assume complete neutrality—
that is, they neglect both direct selection and the effects of selection on linked sites. We here …

It is known that the allele ancestral to the variation at a polymorphic site cannot be assigned
with certainty, and that the most frequently used method to assign the ancestral state …

A faster rate of adaptive evolution of X‐linked genes compared with autosomal genes can
be caused by the fixation of recessive or partially recessive advantageous mutations, due to …

Drosophila melanogaster, a small dipteran of African origin, represents one of the best-
studied model organisms. Early work in this system has uniquely shed light on the basic …

Codon usage bias (CUB), where certain codons are used more frequently than expected by
chance, is a ubiquitous phenomenon and occurs across the tree of life. The dominant …

We used whole-genome resequencing data from a population of Drosophila melanogaster
to investigate the causes of the negative correlation between the within-population …