Trastuzumab is a humanized monoclonal antibody approved for treatment of HER2 (human
epidermal growth factor 2) positive breast cancer. Conjugation of trastuzumab offers a …

Infrared and Raman spectroscopy are effective techniques that allow collecting information
about secondary structure of proteins, including antibodies. Trastuzumab, antibody used in …

Radioimmunoconjugates consists of a monoclonal antibody (mAb) linked to a radionuclide.
Monoclonal antibodies (mAbs) are immunoglobulins able to recognize unique epitopes on a …

Our work was focused on the investigation for a ready to use prepared freeze dried rituximab
immunoconjugates as potential radiopharmaceuticals for labeling with Lu-177 and Y-90 in …

Monoclonal antibodies (mAbs) are currently assessed as a significant and growing class of
drugs of biological origin. The goal of our investigation was to introduce and standardize an …

The human epidermal growth factor receptor (HER2) is overexpressed on a surface of the
cells in aggressive breast cancer. HER2 positive breast cancers without anti-HER2 therapy …

The purpose of this analysis is to explain the usage of animal model in pharmacokinetic-
pharmacodynamic (PK/PD) behavior of conjugated antibodies intended for radioactive …

Ames test or analysis of reversible mutation of Salmonella typhimurium is a test for
identification or detection (screening) of substances that cause genotoxicity or have a …

Monoclonal antibody-based therapy is one of the most successful therapeutic approaches
for solid tumors and other malignancies. Radiolabeling of antibodies with radioisotopes …

Antibody based methods have numerous advantages compared to other detection methods.
However, heavy metals cannot stimulate the immune antibody response; it is the main …