Pain is a multidimensional experience with sensory-discriminative, affective-motivational,
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …

Placebo effects are beneficial effects that are attributable to the brain–mind responses to the
context in which a treatment is delivered rather than to the specific actions of the drug. They …

'How Emotions Are Made did what all great books do. It took a subject I thought I understood
and turned my understanding upside down'–Malcolm Gladwell, author of The Tip** Point …

The mechanisms underlying analgesia related to social touch are not clear. While recent
research highlights the role of the empathy of the observer to pain relief in the target, the …

The brain systems underlying placebo analgesia are insufficiently understood. Here we
performed a systematic, participant-level meta-analysis of experimental functional …

This Perspective reviews recent findings in placebo hypoalgesia and provides a conceptual
account of how expectations and experience can lead to placebo hypoalgesia. In particular …

Social interactions such as the patient–clinician encounter can influence pain, but the
underlying dynamic interbrain processes are unclear. Here, we investigated the dynamic …

Empathy for pain activates brain areas partially overlap** with those underpinning the first-
hand experience of pain. It remains unclear, however, whether such shared activations …

Importance Anhedonia, a reduced capacity for pleasure, is described for many psychiatric
and neurologic conditions. However, a decade after the Research Domain Criteria launch …

Inter-individual touch can be a desirable reward that can both relieve negative affect and
evoke strong feelings of pleasure. However, if other sensory cues indicate it is undesirable …