Peripheral inflammation and blood–brain barrier disruption: effects and mechanisms
X Huang, B Hussain, J Chang - CNS neuroscience & …, 2021 - Wiley Online Library
The blood–brain barrier (BBB) is an important physiological barrier that separates the
central nervous system (CNS) from the peripheral circulation, which contains inflammatory …
central nervous system (CNS) from the peripheral circulation, which contains inflammatory …
Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery
Design and functionalization strategies for multifunctional nanocarriers (eg, nanoparticles,
micelles, polymersomes) based on biodegradable/biocompatible polymers intended to be …
micelles, polymersomes) based on biodegradable/biocompatible polymers intended to be …
Oxidative Stress‐Mediated Blood‐Brain Barrier (BBB) Disruption in Neurological Diseases
K Song, Y Li, H Zhang, N An, Y Wei… - Oxidative medicine …, 2020 - Wiley Online Library
The blood‐brain barrier (BBB), as a crucial gate of brain‐blood molecular exchange, is
involved in the pathogenesis of multiple neurological diseases. Oxidative stress is caused …
involved in the pathogenesis of multiple neurological diseases. Oxidative stress is caused …
Targeting receptor-mediated transport for delivery of biologics across the blood-brain barrier
JM Lajoie, EV Shusta - Annual review of pharmacology and …, 2015 - annualreviews.org
Biologics are an emerging class of medicines with substantial promise to treat neurological
disorders such as Alzheimer's disease, stroke, and multiple sclerosis. However, the blood …
disorders such as Alzheimer's disease, stroke, and multiple sclerosis. However, the blood …
Nanocarriers for the treatment of glioblastoma multiforme: current state-of-the-art
Glioblastoma multiforme, a grade IV glioma, is the most frequently occurring and invasive
primary tumor of the central nervous system, which causes about 4% of cancer-associated …
primary tumor of the central nervous system, which causes about 4% of cancer-associated …
[HTML][HTML] Formation and maintenance of the BBB
M Blanchette, R Daneman - Mechanisms of development, 2015 - Elsevier
The central nervous system (CNS) is vascularized by a dense capillary network that is
critical to deliver oxygen and nutrients, and remove carbon dioxide and waste products, from …
critical to deliver oxygen and nutrients, and remove carbon dioxide and waste products, from …
Nanoscale drug delivery systems and the blood–brain barrier
The protective properties of the blood–brain barrier (BBB) are conferred by the intricate
architecture of its endothelium coupled with multiple specific transport systems expressed on …
architecture of its endothelium coupled with multiple specific transport systems expressed on …
Fingolimod: direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy
Fingolimod is the first oral disease-modifying therapy approved for relapsing forms of
multiple sclerosis (MS). Following phosphorylation in vivo, the active agent, fingolimod …
multiple sclerosis (MS). Following phosphorylation in vivo, the active agent, fingolimod …
Development and function of the blood-brain barrier in the context of metabolic control
R Haddad-Tóvolli, NRV Dragano… - Frontiers in …, 2017 - frontiersin.org
Under physiological conditions, the brain consumes over 20% of the whole body energy
supply. The blood-brain barrier (BBB) allows dynamic interactions between blood capillaries …
supply. The blood-brain barrier (BBB) allows dynamic interactions between blood capillaries …
Oxidative stress and natural antioxidants: Back and forth in the neurological mechanisms of Alzheimer's Disease
Alzheimer's disease (AD) is characterized by the progressive degeneration of neuronal
cells. With the increase in aged population, there is a prevalence of irreversible …
cells. With the increase in aged population, there is a prevalence of irreversible …