Enhancers are genomic sequences that play a key role in regulating tissue-specific gene
expression levels. An increasing number of diseases are linked to impaired enhancer …

Ischemic disease is a class of diseases in which an organ is ischemic due to vascular
occlusion, a major contributor to death and disability worldwide. However, when the blood …

Renal proximal tubule epithelial cells have considerable intrinsic repair capacity following
injury. However, a fraction of injured proximal tubule cells fails to undergo normal repair and …

Background AKI triggers a proliferative response as part of an intrinsic cellular repair
program, which can lead to adaptive renal repair, restoring kidney structure and function, or …

Acute kidney injury (AKI) exhibits high morbidity and mortality. Kidney injury molecule-1
(KIM1) is dramatically upregulated in renal tubules upon injury, and acts as a biomarker for …

Incomplete repair after acute kidney injury can lead to development of chronic kidney
disease. To define the mechanism of this response, we compared mice subjected to …

Herein, we designed and synthesized a novel microRNA (miR)-responsive nanoantenna
capable of early diagnosis and smart treatment of acute kidney injury (AKI). The …

There is a need to define regions of gene activation or repression that control human kidney
cells in states of health, injury, and repair to understand the molecular pathogenesis of …

Background AKI is a significant public health problem with high morbidity and mortality.
Unfortunately, no definitive treatment is available for AKI. RNA interference (RNAi) provides …

Acute kidney injury (AKI) is a severe renal dysfunction syndrome associated with high
morbidity and mortality. Excessive production of reactive oxygen/nitrogen species (RONS) is …