Major depressive disorder

W Marx, BWJH Penninx, M Solmi… - Nature Reviews …, 2023 - nature.com
Major depressive disorder (MDD) is characterized by persistent depressed mood, loss of
interest or pleasure in previously enjoyable activities, recurrent thoughts of death, and …

Gut microbiota and its metabolites in depression: from pathogenesis to treatment

L Liu, H Wang, X Chen, Y Zhang, H Zhang, P **e - EBioMedicine, 2023 - thelancet.com
Major depressive disorder is one of the most disabling mental disorders worldwide.
Increasing preclinical and clinical studies have highlighted that compositional and functional …

Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii

G Liu, DB Catacutan, K Rathod, K Swanson… - Nature Chemical …, 2023 - nature.com
Acinetobacter baumannii is a nosocomial Gram-negative pathogen that often displays
multidrug resistance. Discovering new antibiotics against A. baumannii has proven …

Molecular pathways of major depressive disorder converge on the synapse

GR Fries, VA Saldana, J Finnstein, T Rein - Molecular Psychiatry, 2023 - nature.com
Major depressive disorder (MDD) is a psychiatric disease of still poorly understood
molecular etiology. Extensive studies at different molecular levels point to a high complexity …

Time for united action on depression: a Lancet–World Psychiatric Association Commission

H Herrman, V Patel, C Kieling, M Berk, C Buchweitz… - The Lancet, 2022 - thelancet.com
Executive summary “Depression is a disorder of mood, so mysteriously painful and elusive
in the way it becomes known to the self—to the mediating intellect—as to verge close to …

Gut microbiome–brain alliance: a landscape view into mental and gastrointestinal health and disorders

JM Sasso, RM Ammar, R Tenchov… - ACS Chemical …, 2023 - ACS Publications
Gut microbiota includes a vast collection of microorganisms residing within the
gastrointestinal tract. It is broadly recognized that the gut and brain are in constant …

A systematic review of gut microbiota composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia

AJ McGuinness, JA Davis, SL Dawson… - Molecular …, 2022 - nature.com
The emerging understanding of gut microbiota as 'metabolic machinery'influencing many
aspects of physiology has gained substantial attention in the field of psychiatry. This is …

Irritable bowel syndrome and mental health comorbidity—approach to multidisciplinary management

HM Staudacher, CJ Black, SB Teasdale… - Nature Reviews …, 2023 - nature.com
Irritable bowel syndrome (IBS) affects 5–10% of the global population. Up to one-third of
people with IBS also experience anxiety or depression. Gastrointestinal and psychological …

Perturbations in gut microbiota composition in psychiatric disorders: a review and meta-analysis

VL Nikolova, MRB Smith, LJ Hall, AJ Cleare… - JAMA …, 2021 - jamanetwork.com
Importance Evidence of gut microbiota perturbations has accumulated for multiple
psychiatric disorders, with microbiota signatures proposed as potential biomarkers …

[HTML][HTML] The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders

K Socała, U Doboszewska, A Szopa, A Serefko… - Pharmacological …, 2021 - Elsevier
Emerging evidence indicates that the gut microbiota play a crucial role in the bidirectional
communication between the gut and the brain suggesting that the gut microbes may shape …