Iron is an essential but potentially hazardous biometal. Mammalian cells require sufficient
amounts of iron to satisfy metabolic needs or to accomplish specialized functions. Iron is …

Cellular iron homeostasis is maintained by iron regulatory proteins 1 and 2 (IRP1 and IRP2).
IRPs bind to iron-responsive elements (IREs) located in the untranslated regions of mRNAs …

Abstract Iron–sulphur (Fe–S) clusters have long been recognized as essential and versatile
cofactors of proteins involved in catalysis, electron transport and sensing of ambient …

Mitochondria play a key role in iron metabolism in that they synthesize heme, assemble iron–
sulfur (Fe/S) proteins, and participate in cellular iron regulation. Here, we review the latter …

Mammalian adrenodoxin (ferredoxin 1; Fdx1) is essential for the synthesis of various steroid
hormones in adrenal glands. As a member of the [2Fe-2S] cluster-containing ferredoxin …

Abstract Iron–sulfur (Fe–S) clusters are versatile protein cofactors that require numerous
components for their synthesis and insertion into apoproteins. In eukaryotes, maturation of …

Iron-sulfur (Fe-S) clusters are ubiquitous cofactors composed of iron and inorganic sulfur.
They are required for the function of proteins involved in a wide range of activities, including …

Abstract Iron–sulphur (Fe–S) clusters are inorganic cofactors that are found in nearly all
species and are composed of various combinations of iron and sulphur atoms. Fe–S clusters …

Instability of the nuclear genome is a hallmark of cancer and aging. MMS19 protein has
been linked to maintenance of genomic integrity, but the molecular basis of this connection …

We report on ten individuals with a fatal infantile encephalopathy and/or pulmonary
hypertension, leading to death before the age of 15 months. Hyperglycinemia and lactic …