Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

A revolution in the field of biocatalysis has enabled scalable access to compounds of high
societal values using enzymes. The construction of biocatalytic routes relies on the reservoir …

Human-associated bacteria secrete modified peptides to control host physiology and
remodel the microbiota species composition. Here we scanned 2,229 Human Microbiome …

Bioengineering of ribosomally synthesized and post-translationally modified peptides
(RiPPs) is an emerging approach to explore the diversity of pseudo-natural product …

Broad substrate tolerance of ribosomally synthesized and post-translationally modified
peptide (RiPP) biosynthetic enzymes has allowed numerous strategies for RiPP …

Peptide natural products are important lead structures for human drugs and many
nonribosomal peptides possess antibiotic activity. This makes them interesting targets for …

The era of inexpensive genome sequencing and improved bioinformatics tools has
reenergized the study of natural products, including the ribosomally synthesized and post …

Inteins are proteins found in nature that execute protein splicing. Among them, split inteins
stand out for their versatility and adaptability, presenting creative solutions for addressing …

The Burkholderia cepacia complex (Bcc) is a group of bacteria including opportunistic
human pathogens. Immunocompromised individuals and cystic fibrosis patients are …

Highlights•Peptide diversification by posttranslational modification of precursor
proteins.•Genome mining functionally diverse protein superfamilies yields RiPP …