DNA-empowered synthetic cells as minimalistic life forms

A Samanta, L Baranda Pellejero, M Masukawa… - Nature Reviews …, 2024 - nature.com
Cells, the fundamental units of life, orchestrate intricate functions—motility, adaptation,
replication, communication, and self-organization within tissues. Originating from …

Spatially localized entropy-driven evolution of nucleic acid-based constitutional dynamic networks for intracellular imaging and spatiotemporal programmable gene …

N Lin, Y Ouyang, Y Qin, O Karmi, YS Sohn… - Journal of the …, 2024 - ACS Publications
The primer-guided entropy-driven high-throughput evolution of the DNA-based
constitutional dynamic network, CDN, is introduced. The entropy gain associated with the …

A facile DNA coacervate platform for engineering wetting, engulfment, fusion and transient behavior

W Liu, J Deng, S Song, S Sethi, A Walther - Communications Chemistry, 2024 - nature.com
Biomolecular coacervates are emerging models to understand biological systems and
important building blocks for designer applications. DNA can be used to build up …

Artificial cells with viscoadaptive behavior based on hydrogel-loaded giant unilamellar vesicles

A Llopis-Lorente, MJG Schotman, HV Humeniuk… - Chemical …, 2024 - pubs.rsc.org
Viscoadaptation is an essential process in natural cells, where supramolecular interactions
between cytosolic components drive adaptation of the cellular mechanical features to …

Coacervate Droplets as Biomimetic Models for Designing Cell‐Like Microreactors

T Ivanov, TP Doan‐Nguyen… - Macromolecular …, 2024 - Wiley Online Library
Coacervates are versatile compartments formed by liquid–liquid phase separation. Their
dynamic behavior and molecularly crowded microenvironment make them ideal materials …

Construction of the Glycolysis Metabolic Pathway Inside an Artificial Cell for the Synthesis of Amino Acid and Its Reversible Deformation

B Yang, C Li, Y Ren, W Wang, X Zhang… - Journal of the American …, 2024 - ACS Publications
The bottom-up construction of artificial cells is beneficial for understanding cell working
mechanisms. The glycolysis metabolism mimicry inside artificial cells is challenging. Herein …

Kinetic Trap** of an Out‐of‐Equilibrium Dynamic Library of Imines by Changing Solvent

M Valentini, G Ercolani… - Chemistry–A European …, 2024 - Wiley Online Library
A well‐behaved dynamic library composed of two imines and corresponding amines was
subjected to the action of an activated carboxylic acid (ACA), whose decarboxylation is …

Liquid DNA coacervates form porous capsular hydrogels via viscoelastic phase separation on microdroplet interface

M Morita, T Sakamoto, SM Nomura… - Advanced Materials …, 2024 - Wiley Online Library
Liquid–liquid phase separation (LLPS) droplets of biopolymers are known as functional
microdroplets in living cells and have recently been used to construct protocells and artificial …

Organelle-like structural evolution of coacervate droplets induced by photopolymerization

M Zhu, Z Li, J Li, Y Lin, H Chen, X Qiao, X Wang… - Nature …, 2025 - nature.com
The dynamic study of coacervates in vitro contributes our understanding of phase separation
mechanisms in cells due to complex intracellular physiology. However, current researches …

Noncanonical condensation of nucleic acid chains by hydrophobic gold nanocrystals

Y Li, H Zheng, H Lu, M Duan, C Li, M Li, J Li, L Wang… - JACS Au, 2023 - ACS Publications
Nucleic acid condensates are essential for various biological processes and have numerous
applications in nucleic acid nanotechnology, gene therapy, and mRNA vaccines. However …