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DNA-empowered synthetic cells as minimalistic life forms
Cells, the fundamental units of life, orchestrate intricate functions—motility, adaptation,
replication, communication, and self-organization within tissues. Originating from …
replication, communication, and self-organization within tissues. Originating from …
Spatially localized entropy-driven evolution of nucleic acid-based constitutional dynamic networks for intracellular imaging and spatiotemporal programmable gene …
The primer-guided entropy-driven high-throughput evolution of the DNA-based
constitutional dynamic network, CDN, is introduced. The entropy gain associated with the …
constitutional dynamic network, CDN, is introduced. The entropy gain associated with the …
A facile DNA coacervate platform for engineering wetting, engulfment, fusion and transient behavior
Biomolecular coacervates are emerging models to understand biological systems and
important building blocks for designer applications. DNA can be used to build up …
important building blocks for designer applications. DNA can be used to build up …
Artificial cells with viscoadaptive behavior based on hydrogel-loaded giant unilamellar vesicles
A Llopis-Lorente, MJG Schotman, HV Humeniuk… - Chemical …, 2024 - pubs.rsc.org
Viscoadaptation is an essential process in natural cells, where supramolecular interactions
between cytosolic components drive adaptation of the cellular mechanical features to …
between cytosolic components drive adaptation of the cellular mechanical features to …
Coacervate Droplets as Biomimetic Models for Designing Cell‐Like Microreactors
T Ivanov, TP Doan‐Nguyen… - Macromolecular …, 2024 - Wiley Online Library
Coacervates are versatile compartments formed by liquid–liquid phase separation. Their
dynamic behavior and molecularly crowded microenvironment make them ideal materials …
dynamic behavior and molecularly crowded microenvironment make them ideal materials …
Construction of the Glycolysis Metabolic Pathway Inside an Artificial Cell for the Synthesis of Amino Acid and Its Reversible Deformation
B Yang, C Li, Y Ren, W Wang, X Zhang… - Journal of the American …, 2024 - ACS Publications
The bottom-up construction of artificial cells is beneficial for understanding cell working
mechanisms. The glycolysis metabolism mimicry inside artificial cells is challenging. Herein …
mechanisms. The glycolysis metabolism mimicry inside artificial cells is challenging. Herein …
Kinetic Trap** of an Out‐of‐Equilibrium Dynamic Library of Imines by Changing Solvent
M Valentini, G Ercolani… - Chemistry–A European …, 2024 - Wiley Online Library
A well‐behaved dynamic library composed of two imines and corresponding amines was
subjected to the action of an activated carboxylic acid (ACA), whose decarboxylation is …
subjected to the action of an activated carboxylic acid (ACA), whose decarboxylation is …
Liquid DNA coacervates form porous capsular hydrogels via viscoelastic phase separation on microdroplet interface
Liquid–liquid phase separation (LLPS) droplets of biopolymers are known as functional
microdroplets in living cells and have recently been used to construct protocells and artificial …
microdroplets in living cells and have recently been used to construct protocells and artificial …
Organelle-like structural evolution of coacervate droplets induced by photopolymerization
M Zhu, Z Li, J Li, Y Lin, H Chen, X Qiao, X Wang… - Nature …, 2025 - nature.com
The dynamic study of coacervates in vitro contributes our understanding of phase separation
mechanisms in cells due to complex intracellular physiology. However, current researches …
mechanisms in cells due to complex intracellular physiology. However, current researches …
Noncanonical condensation of nucleic acid chains by hydrophobic gold nanocrystals
Nucleic acid condensates are essential for various biological processes and have numerous
applications in nucleic acid nanotechnology, gene therapy, and mRNA vaccines. However …
applications in nucleic acid nanotechnology, gene therapy, and mRNA vaccines. However …