Somatostatin analogs, such as octreotide, lanreotide, and pasireotide, which function as
somatostatin receptor ligands (SRLs), are the main drugs used for the treatment of …

Traditionally, drugs are monovalent, targeting only one site on the protein surface. This
includes orthosteric and allosteric drugs, which bind the protein at orthosteric and allosteric …

The µ-opioid receptor (µOR) is a well-established target for analgesia, yet conventional
opioid receptor agonists cause serious adverse effects, notably addiction and respiratory …

Despite the increasing number of GPCR structures and recent advances in peptide design,
the development of efficient technologies allowing rational design of high-affinity peptide …

Lipids play a diverse and critical role in cellular processes in all tissues. The unique lipid
composition of nerve membranes is particularly interesting because it contains, among other …

G protein-coupled receptors (GPCRs) play critical roles in human physiology and are one of
the prime targets for marketed drugs. While traditional drug discovery programs have …

Heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors (GPCRs)
bind to extracellular ligands and drugs and modulate intracellular responses through …

Allosteric regulation is critical for the functioning of G protein-coupled receptors (GPCRs)
and their signaling pathways. Endogenous allosteric regulators of GPCRs are simple ions …

The use of deep machine learning (ML) in protein structure prediction has made it possible
to easily access a large number of annotated conformations that can potentially compensate …

The orphan G protein-coupled receptor (oGPCR) GPR3 represents a potential drug target
for the treatment of Alzheimer's disease and metabolic disorders. However, the limited …