Reconstructing organisms in silico: genome-scale models and their emerging applications

X Fang, CJ Lloyd, BO Palsson - Nature Reviews Microbiology, 2020 - nature.com
Escherichia coli is considered to be the best-known microorganism given the large number
of published studies detailing its genes, its genome and the biochemical functions of its …

Virulence of the zoonotic agent of leptospirosis: still terra incognita?

M Picardeau - Nature Reviews Microbiology, 2017 - nature.com
Pathogenic leptospires are the bacterial agents of leptospirosis, which is an emerging
zoonotic disease that affects animals and humans worldwide. The success of leptospires as …

Revisiting the taxonomy and evolution of pathogenicity of the genus Leptospira through the prism of genomics

AT Vincent, O Schiettekatte, C Goarant… - PLoS neglected …, 2019 - journals.plos.org
The causative agents of leptospirosis are responsible for an emerging zoonotic disease
worldwide. One of the major routes of transmission for leptospirosis is the natural …

BiGG Models 2020: multi-strain genome-scale models and expansion across the phylogenetic tree

CJ Norsigian, N Pusarla, JL McConn… - Nucleic acids …, 2020 - academic.oup.com
Abstract The BiGG Models knowledge base (http://bigg. ucsd. edu) is a centralized
repository for high-quality genome-scale metabolic models. For the past 12 years, the …

Leptospiral infection, pathogenesis and its diagnosis—A review

AV Samrot, TC Sean, KS Bhavya, CS Sahithya… - Pathogens, 2021 - mdpi.com
Leptospirosis is a perplexing conundrum for many. In the existing literature, the
pathophysiological mechanisms pertaining to leptospirosis is still not understood in full …

Genus-wide Leptospira core genome multilocus sequence ty** for strain taxonomy and global surveillance

J Guglielmini, P Bourhy, O Schiettekatte… - PLoS neglected …, 2019 - journals.plos.org
Leptospira is a highly heterogeneous bacterial genus that can be divided into three
evolutionary lineages and> 300 serovars. The causative agents of leptospirosis are …

Comprehensive Genome Analysis of Carbapenemase-Producing Enterobacter spp.: New Insights into Phylogeny, Population Structure, and Resistance Mechanisms

KD Chavda, L Chen, DE Fouts, G Sutton, L Brinkac… - MBio, 2016 - journals.asm.org
Knowledge regarding the genomic structure of Enterobacter spp., the second most prevalent
carbapenemase-producing Enterobacteriaceae, remains limited. Here we sequenced 97 …

Evolutionary insights into the emergence of virulent Leptospira spirochetes

A Giraud-Gatineau, C Nieves, LB Harrison… - PLoS …, 2024 - journals.plos.org
Pathogenic Leptospira are spirochete bacteria which cause leptospirosis, a re-emerging
zoonotic disease of global importance. Here, we use a recently described lineage of …

Biodiversity of Environmental Leptospira: Improving Identification and Revisiting the Diagnosis

R Thibeaux, D Girault, E Bierque… - Frontiers in …, 2018 - frontiersin.org
Leptospirosis is an important environmental disease and a major threat to human health
causing at least 1 million clinical infections annually. There has recently been a growing …

Deciphering the unexplored Leptospira diversity from soils uncovers genomic evolution to virulence

R Thibeaux, G Iraola, I Ferrés, E Bierque… - Microbial …, 2018 - microbiologyresearch.org
Despite recent advances in our understanding of the genomics of members of the genus
Leptospira, little is known on how virulence has emerged in this heterogeneous bacterial …