Caspases are an evolutionary conserved family of cysteine-dependent proteases that are
involved in many vital cellular processes including apoptosis, proliferation, differentiation …

Apoptosis is a critically important biological process that plays an essential role in cell fate
and homeostasis. An important component of the apoptotic pathway is the family of proteins …

The process of programmed cell death, or apoptosis, is generally characterized by distinct
morphological characteristics and energy-dependent biochemical mechanisms. Apoptosis is …

Apoptosis—the regulated destruction of a cell—is a complicated process. The decision to
die cannot be taken lightly, and the activity of many genes influence a cell's likelihood of …

Improved mechanistic understanding of renal cell death in acute kidney injury (AKI) has
generated new therapeutic targets. Clearly, the classic lesion of acute tubular necrosis is not …

Mitochondria play an important role in cell death and cardioprotection. During ischemia,
when ATP is progressively depleted, ion pumps cannot function resulting in a rise in calcium …

Reperfusion is a pre-requisite to salvaging viable myocardium, following an acute
myocardial infarction. Reperfusion of ischaemic myocardium, however, is not without risk, as …

Yellon, Derek M., and James M. Downey. Preconditioning the Myocardium: From Cellular
Physiology to Clinical Cardiology. Physiol Rev 83: 1113-1151, 2003; 10.1152/physrev …

Abstract The Fifth Edition of the 'Guide to Receptors and Channels' is a compilation of the
major pharmacological targets divided into seven sections: G protein‐coupled receptors …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …