Aquatic invertebrates play a pivotal role in (eco) toxicological assessments because they
offer ethical, cost‐effective and repeatable testing options. Additionally, their significance in …

Regarding the humane use of animals in scientific research, invertebrates are often
recommended in toxicological studies.“Freshwater planarians” refers to numerous free-living …

Abstract DAPT (N-[N-(3, 5-difluorophenacetyl)-l-alanyl]-s-phenylglycinet-butyl ester) is a γ-
secretase inhibitor that indirectly blocks the activity of Notch pathway. It is a potential …

Planarians have a long history in the fields of developmental and regenerative biology.
These animals have also sparked interest in neuroscience due to their neuroanatomy …

At present, there is a serious concern about the alarming number of recalcitrant
contaminants that can negatively affect biodiversity threatening the ecological status of …

Despite mounting evidence of pleiotropic ecological risks, the understanding of the eco-
neurotoxic impact of most industrially relevant chemicals is still very limited. In particularly …

There is a clear need to establish and validate new methodologies to more quickly and
efficiently screen chemicals for potential toxic effects, particularly on development. The …

Organophosphorus pesticides (OPs) are a chemically diverse class of commonly used
insecticides. Epidemiological studies suggest that low dose chronic prenatal and infant …

There is an increased recognition in the field of toxicology of the value of medium-to-high-
throughput screening methods using in vitro and alternative animal models. We have …

High-throughput screening (HTS) using new approach methods is revolutionizing
toxicology. Asexual freshwater planarians are a promising invertebrate model for …