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[HTML][HTML] Biologics for tendon repair
Tendon injuries are common and present a clinical challenge to orthopedic surgery mainly
because these injuries often respond poorly to treatment and require prolonged …
because these injuries often respond poorly to treatment and require prolonged …
Tendon injury: from biology to tendon repair
Tendon is a crucial component of the musculoskeletal system. Tendons connect muscle to
bone and transmit forces to produce motion. Chronic and acute tendon injuries are very …
bone and transmit forces to produce motion. Chronic and acute tendon injuries are very …
Gene therapy approaches to regenerating the musculoskeletal system
CH Evans, J Huard - Nature Reviews Rheumatology, 2015 - nature.com
Injuries to the musculoskeletal system are common, debilitating and expensive. In many
cases, healing is imperfect, which leads to chronic impairment. Gene transfer might improve …
cases, healing is imperfect, which leads to chronic impairment. Gene transfer might improve …
Transcription factor EGR1 directs tendon differentiation and promotes tendon repair
MJ Guerquin, B Charvet, G Nourissat, E Havis… - The Journal of clinical …, 2013 - jci.org
Tendon formation and repair rely on specific combinations of transcription factors, growth
factors, and mechanical parameters that regulate the production and spatial organization of …
factors, and mechanical parameters that regulate the production and spatial organization of …
Scleraxis is a transcriptional activator that regulates the expression of Tenomodulin, a marker of mature tenocytes and ligamentocytes
C Shukunami, A Takimoto, Y Nishizaki, Y Yoshimoto… - Scientific reports, 2018 - nature.com
Tenomodulin (Tnmd) is a type II transmembrane glycoprotein predominantly expressed in
tendons and ligaments. We found that scleraxis (Scx), a member of the Twist-family of basic …
tendons and ligaments. We found that scleraxis (Scx), a member of the Twist-family of basic …
Progress in cell-based therapies for tendon repair
The last decade has seen significant developments in cell therapies, based on permanently
differentiated, reprogrammed or engineered stem cells, for tendon injuries and degenerative …
differentiated, reprogrammed or engineered stem cells, for tendon injuries and degenerative …
Tendon development and musculoskeletal assembly: emerging roles for the extracellular matrix
Tendons and ligaments are extracellular matrix (ECM)-rich structures that interconnect
muscles and bones. Recent work has shown how tendon fibroblasts (tenocytes) interact with …
muscles and bones. Recent work has shown how tendon fibroblasts (tenocytes) interact with …
Uncovering the cellular and molecular changes in tendon stem/progenitor cells attributed to tendon aging and degeneration
Although the link between altered stem cell properties and tissue aging has been
recognized, the molecular and cellular processes of tendon aging have not been elucidated …
recognized, the molecular and cellular processes of tendon aging have not been elucidated …
Nucleic acid delivery to mesenchymal stem cells: a review of nonviral methods and applications
Abstract Background Mesenchymal stem cells (MSCs) are multipotent stem cells that can be
isolated and expanded from many tissues, and are being investigated for use in cell …
isolated and expanded from many tissues, and are being investigated for use in cell …
Mohawk promotes the tenogenesis of mesenchymal stem cells through activation of the TGFβ signaling pathway
Abstract The transcription factor Mohawk (Mkx) is expressed in develo** tendons and is
an important regulator of tenogenic differentiation. However, the exact roles of Mkx in …
an important regulator of tenogenic differentiation. However, the exact roles of Mkx in …